Lung Surfactant: Cellular and Molecular Biology

描述(由申请人提供)： 这项申请是为将于2004年7月24-29日在佛蒙特州萨克斯顿河佛蒙特学院举行的FASEB肺表面活性物质：细胞和分子生物学夏季会议提供部分资金。出席人数限制为160人，以创造有利于互动的氛围。本次会议的总体目标是提供一个论坛，交流关于胎肺发育和表面活性物质产生细胞分化的基本分子和细胞生物学，表面活性物质和蛋白质合成、运输和分泌的调节机制的最新和最前沿的信息。将讨论表面活性蛋白质作为先天免疫系统组成部分的作用，以及它们在哺乳动物生理学中的新作用以及它们的结构与功能的关系。会议还将强调表面活性物质系统的病理生理学，涉及蛋白质错误折叠和疾病、肺损伤和修复。我们认为，这次会议是独一无二的，非常重要，因为除了邀请表面活性物质领域公认的专家外，我们还邀请了在不同但相关学科工作的知名专家，以提供干细胞生物学和器官发生、蛋白质错误折叠、细胞器生物形成和贩运以及宿主防御领域的深入信息。本次会议讨论的主题包括：(1)干细胞命运的调控，肺干细胞的起源，表面活性物质产生细胞的分化机制，以及II型细胞向I型细胞的转分化；(2)参与器官发生、细胞分化和肺泡上皮细胞特化功能的转录机制；(3)II型细胞对表面活性物质脂类和蛋白质的细胞器生物发生和胞吐作用；(4)表面活性蛋白折叠在运输和病理生理中的作用；(5)表面活性物质稳态的调节和参与这一过程的病理生理机制；(6)表面活性蛋白A和D作为肺泡内天然免疫系统的组成部分的作用；(7)表面活性蛋白的结构分析和蛋白质结构与功能的关系；(8)肺损伤的机制和评价成人呼吸窘迫综合征治疗方案的临床试验结果。这次会议的一个主要目标是创建一个论坛，以传播新的信息，并促进表面活性剂领域的知名和初级研究人员与具有不同背景和专业领域的杰出科学家的互动。我们相信，这次会议将为未来表面活性剂领域的研究提供一个新的方法和方向的框架。

DESCRIPTION (provided by applicant): This application is for partial funding of a FASEB Summer Conference on Lung Surfactant: Cellular and Molecular Biology to be held July 24 - 29, 2004 at The Vermont Academy, Saxtons River, VT. Attendance is limited to 160 persons to create a climate conducive to interaction. The overall objective of this conference is to provide a forum for exchange of new and cutting-edge information regarding the basic molecular and cellular biology of fetal lung development and differentiation of surfactant producing cells, mechanisms in the regulation of synthesis, trafficking and secretion of surfactant lipids and proteins. The role of surfactant proteins as components of the innate immune system will be considered, as well as their novel roles in mammalian physiology and the relationship of their structure to function. The conference also will emphasize the pathophysiology of the surfactant system, with regard to protein misfolding and disease, lung injury and repair. We believe that this meeting is unique and highly important because, in addition to inviting speakers who are recognized experts in the surfactant field, we have included renowned experts working in different but related disciplines to provide in-depth information in the areas of stem cell biology and organogenesis, protein misfolding, organelle biogenesis and trafficking and host defense. The topics considered in this conference include: (1) regulation of stem cell fate, origin of lung stem cells, mechanisms in differentiation of surfactant-producing cells, and in type II cell to type I cell transdifferentiation; (2) transcriptional mechanisms involved in organogenesis, cellular differentiation and specialized function of alveolar epithelial cells; (3) organelle biogenesis and exocytosis of surfactant lipids and proteins by type II cells; (4) role of surfactant protein folding in trafficking and pathophysiology; (5) regulation of surfactant homeostasis and mechanisms involved in the pathophysiology of this process; (6) roles of surfactant proteins A and D as components of the innate immune system within the lung alveolus; (7) structural analysis of the surfactant proteins and relationship of protein structure to function; (8) mechanisms of lung injury and results of clinical trials evaluating treatment regimens for adult respiratory distress syndrome. A major goal of this conference is to create a forum to disseminate new information and promote the interaction of established and junior investigators in the surfactant field with outstanding scientists of different backgrounds and areas of expertise. We believe that this meeting will provide a framework for novel approaches and directions for future research in the surfactant field.