Nuclear Receptors: Steroid Sisters

描述（由申请人提供）： 本次会议的总体目标是提供核受体领域最重要和最新的研究。主题将包括核受体在生理和病理生理状态，发育和代谢过程的调节中的作用。核受体辅助调节相互作用，在染色质重塑和转录激活和抑制机制也将被解决，将类固醇受体的细胞核信号的机制。将考虑作为药物发现的潜在靶点的辅助调节剂和核受体的作用，以及与配体，辅因子和DNA复合的受体结构域的结构特性。我们的目标是突出最新的生物工具（例如，动物模型、新型配体、结构信息）和技术（例如，基因组学、蛋白质组学、配体筛选），可用于核受体研究，并促进学术机构和工业界科学家的富有成效的互动。我们将讨论核受体在健康和疾病中的作用，以及利用这些知识开发治疗内分泌和代谢疾病的新药。会议地点还将促进该领域的主要专家与年轻科学家和受训人员的互动，特别强调将代表性不足的群体包括在内。

DESCRIPTION (provided by applicant): The overall goal of this conference is to provide the most important and up-to-date research in the nuclear receptor field. Topics presented will include the roles of nuclear receptors in physiologic and pathophysiologic states, in development and in regulation of metabolic processes. Nuclear receptor-coregulator interactions, mechanisms in chromatin remodeling and transcriptional activation and repression also will be addressed, as will mechanisms of extranuclear signaling by steroid receptors. The roles of coregulators and nuclear receptors as potential targets for drug discovery will be considered, as well as structural properties of receptor domains complexed with ligands, cofactors, and DNA. It is our objective to highlight the latest biological tools (e.g., animal models, novel ligands, structural information) and technologies (e.g., genomics, proteomics, ligand screening) available for nuclear receptor research and promote the productive interaction of scientists from academic institutions and industry. We will address actions of nuclear receptors in health and disease, and the use of this knowledge for development of new drugs for treatment of endocrine and metabolic diseases. The meeting venue also will facilitate the interaction of leading experts in the field with younger scientists and trainees, with a particular emphasis on the inclusion of under represented groups.