Active Dendrites in Motor Neurons

运动神经元中的活跃树突

• 批准号: 6801732
• 负责人: ROGER M. ENOKA
• 金额: $ 0.8万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-06-01 至 2005-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6801732
• 关键词: dendrites; meeting /conference /symposium; motor neurons; neural transmission; psychomotor function

DESCRIPTION (provided by applicant): In the classic view of spinal cord neurophysiology, the thousands of synaptic inputs that impinge on motor neurons are integrated and converted to action potentials. In recent years, however, it has become evident that he dendrites of motor neurons do not act as passive recipients of synaptic input; they contain voltage-sensitive onductances that are influenced by neuromodulatory input from monoaminergic axons originating in the brainstem: At high levels of monoaminergic input, the persistent inward currents that are generated in the dendrites become so large that the discharge rates required for maximal activation of muscle fibers can be achieved with relatively minor amounts of synaptic input. Thus, active dendritic currents rather than ionotropic synaptic currents may dominate integration by motor neurons during normal motor behavior. One consequence of this possibility is that it becomes difficult to infer patterns of synaptic input from recordings of motor unit activity made in human subjects and patients. The purpose of this R13 application is to request support for a 3-day meeting that will provide a forum for the exchange of information between investigators who study motor neuron properties in experimental animals and those who record motor unit activity in humans. The meeting, which is titled "'Active Dendrites in Motor Neurons: Mechanisms and Effects on Motor Output", will be held at the University of Colorado at Boulder on June 24-26, 2004. The meeting will involve about 75 participants: 26 invited speakers, approximately 30 trainees (graduate students and postdoctoral fellows), and a number of collaborators. The invited speakers, all of whom have agreed to participate in the meeting, are PIs who direct research programs that study either motor neuron properties in experimental animals or motor unit activity in humans. Nine of the 26 invited speakers are women. The meeting format will consist of podium presentations (30, 10, and 2 rain), poster sessions, and significant time for discussion. The meeting will also include three young investigator awards to encourage participation by trainees in the meeting. The abstracts submitted by each invited speaker will be posted on a publicized website. Our expectation is that the meeting will provide an opportunity to review current knowledge on motor neuron properties and motor unit behavior, to identify critical gaps in existing knowledge, and to formulate a research agenda that can address these issues.

描述（由申请人提供）： 在脊髓神经生理学的经典观点中，撞击运动神经元的数千个突触输入被整合并转化为动作电位。然而，近年来，运动神经元的树突并不是突触输入的被动接受者，它们含有电压敏感性传导，受到来自脑干的单胺能轴突的神经调节输入的影响：在高水平的单胺能输入下，在树突中产生的持续的内向电流变得如此之大，以致于肌纤维的最大激活所需的放电速率可以可以用相对少量的突触输入来实现。因此，活跃的树突电流，而不是亲离子性突触电流可能占主导地位的整合运动神经元在正常的运动行为。这种可能性的一个后果是，从人类受试者和患者的运动单位活动记录中推断突触输入的模式变得困难。本R13应用程序的目的是请求支持为期3天的会议，该会议将为研究实验动物运动神经元特性的研究者和记录人类运动单位活动的研究者之间的信息交换提供论坛。这次会议的题目是“运动神经元中的活性树突：对运动输出的机制和影响”，会议将于2004年6月24-26日在博尔德的科罗拉多大学举行。会议将有大约75名与会者参加：26名特邀演讲者、大约30名受训人员（研究生和博士后研究员）和一些合作者。受邀的演讲者都同意参加会议，他们都是PI，负责研究实验动物运动神经元特性或人类运动单元活动的研究项目。26名受邀演讲者中有9名是女性。会议形式将包括讲台演讲（30，10和2雨），海报会议和重要的讨论时间。会议还将颁发三个青年调查员奖，以鼓励受训人员参加会议。每位受邀发言者提交的摘要将张贴在一个公开网站上。我们的期望是，这次会议将提供一个机会，审查目前的知识运动神经元的属性和运动单位的行为，以确定现有知识的关键差距，并制定一个研究议程，可以解决这些问题。