A BioPhysical Approach to Resuscitation Fluids

复苏液的生物物理学方法

• 批准号: 6883033
• 负责人: Bashir A. ZIKRIA
• 金额: $ 11.18万
• 依托单位: BIOPHYZICA, INC.
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-03-02 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6883033
• 关键词: antioxidants; ascorbate; biomaterial development /preparation; blood /plasma substitute; capillary; cerebral ischemia /hypoxia; heart arrest; infant animal; macromolecule; nervous system disorder; nonhuman therapy evaluation; reperfusion; resuscitation; starch; swine; vascular endothelium permeability

DESCRIPTION (provided by applicant): Circulatory, hypoxemic or traumatic arrest claims an estimated 350,000 lives per year in the United States accounting for almost 15% of all deaths. Circulatory, hypoxemic, or traumatic arrests result in whole-body ischemia, most significantly global cerebral ischemia. Brain cells die when they no longer receive oxygen and nutrients from the blood. Because cerebral blood flow is inadequate during CPR, the likelihood of neurologically intact survival diminishes rapidly with time. Irreversible brain damage begins to occur within 4 to 5 minutes of cardiac arrest if there is no intervention. Restoration of circulation after 5 to 20 minutes of ischemia is accompanied by variable degrees of neurologic damage. BioPhyZica has developed a treatment, known as HES-Z + VitC for treating capillary leak, edema, and reperfusion injury. The hydroxyethyl starch component provides a biophysical action of sealing at the enlarged capillary endothelial gaps (pores) that develop with increased capillary permeability after arrest, while the antioxidant enhances the overall efficacy by reducing reperfusion injury. During Phase I, BioPhyZica and the Medical College of Wisconsin will demonstrate proof of concept by using an animal model of global cerebral ischemia to demonstrate that treatment with HES-Z + VitC will reduce mortality and neurological deficit.

描述（由申请人提供）：在美国，循环、低氧血症或创伤性心脏骤停估计每年造成35万人死亡，占所有死亡人数的近15%。循环、低氧血症或创伤性停搏导致全身缺血，最显著的是全脑缺血。当脑细胞不再从血液中获得氧气和营养时，它们就会死亡。由于心肺复苏术时脑血流量不足，神经系统完好存活的可能性会随着时间的推移而迅速降低。如果不进行干预，心脏骤停后4至5分钟内就开始出现不可逆的脑损伤。缺血5至20分钟后循环恢复伴随着不同程度的神经损伤。BioPhyZica开发了一种治疗方法，称为HES-Z + VitC，用于治疗毛细血管渗漏，水肿和再灌注损伤。羟乙基淀粉组分提供了在扩大的毛细血管内皮间隙（孔）处密封的生物物理作用，所述毛细血管内皮间隙（孔）在停滞后随着毛细血管渗透性增加而发展，而抗氧化剂通过减少再灌注损伤来增强总体功效。在第一阶段，BioPhyZica和威斯康星州医学院将通过使用全脑缺血动物模型来证明概念验证，以证明HES-Z + VitC治疗将降低死亡率和神经功能缺损。