A BioPhysical approach to Resuscitation Fluids

描述(由申请人提供)：在美国，循环系统、低氧血症或创伤性逮捕每年造成约35万人死亡，几乎占所有死亡人数的15%。循环、低氧或创伤性停搏会导致全身缺血，最显著的是全脑缺血。当脑细胞不再从血液中获得氧气和营养时，它们就会死亡。由于心肺复苏术期间脑血流不足，神经功能完好存活的可能性随着时间的推移而迅速降低。如果不进行干预，心脏骤停后4至5分钟内就会开始发生不可逆转的脑损伤。脑缺血5到20分钟后恢复循环伴随着不同程度的神经损伤。BioPhyZica已经开发出一种名为HES-Z+VitC的治疗方法，用于治疗毛细血管渗漏、浮肿和再灌注损伤。羟乙基淀粉成分提供了封闭扩大的毛细血管内皮细胞间隙(气孔)的生物物理作用，这些气孔在停搏后随着毛细血管通透性的增加而发展，而抗氧化剂则通过减少再灌注损伤来增强整体疗效。在第一阶段，BioPhyZica和威斯康星医学院将通过使用全球脑缺血的动物模型来证明概念，以证明使用HES-Z+VitC治疗将减少死亡率和神经缺陷。

DESCRIPTION (provided by applicant): Circulatory, hypoxemic or traumatic arrest claims an estimated 350,000 lives per year in the United States accounting for almost 15% of all deaths. Circulatory, hypoxemic, or traumatic arrests result in whole-body ischemia, most significantly global cerebral ischemia. Brain cells die when they no longer receive oxygen and nutrients from the blood. Because cerebral blood flow is inadequate during CPR, the likelihood of neurologically intact survival diminishes rapidly with time. Irreversible brain damage begins to occur within 4 to 5 minutes of cardiac arrest if there is no intervention. Restoration of circulation after 5 to 20 minutes of ischemia is accompanied by variable degrees of neurologic damage. BioPhyZica has developed a treatment, known as HES-Z + VitC for treating capillary leak, edema, and reperfusion injury. The hydroxyethyl starch component provides a biophysical action of sealing at the enlarged capillary endothelial gaps (pores) that develop with increased capillary permeability after arrest, while the antioxidant enhances the overall efficacy by reducing reperfusion injury. During Phase I, BioPhyZica and the Medical College of Wisconsin will demonstrate proof of concept by using an animal model of global cerebral ischemia to demonstrate that treatment with HES-Z + VitC will reduce mortality and neurological deficit.