Diffraction Enhanced Imaging Laboratory Research Machine

衍射增强成像实验室研究机

• 批准号: 6885256
• 负责人: Oliver Joel
• 金额: $ 10万
• 依托单位: NESCH, LLC.
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6885256
• 关键词: X ray; bioimaging /biomedical imaging; computer human interaction; computer program /software; electromagnetic radiation; image processing; imaging /visualization /scanning; synchrotrons; technology /technique development

DESCRIPTION (provided by applicant): Diffraction enhanced imaging (DEI) is a novel approach to X-ray imaging that has the potential to revolutionize X-ray medical imaging, because of its greater contrast at lower delivered X-ray doses than conventional radiography. DEI relies on measuring tiny angular deflections of a collimated X-ray beam as it passes through the object (patient) in acquiring the images. The capability of DEI to detect low-density features in low-density matrices will make it especially useful in medical diagnoses and research. DEI is currently limited to synchrotron radiation facilities, but the potential impact of this technology in medical imaging research, and subsequently in clinical use, will far exceed the current or projected capacity of available synchrotron beamlines. We propose to develop DEI Laboratory Research Machine for medical imaging research. Its successful development, with acceptable image acquisition times, contrast and resolution would provide the knowledge base necessary for subsequent commercialization - a key to DEI's wider use and development of the imaging technology itself - along with the development of appropriate imaging protocols and methods. This project would thus provide the requisite "springboard technology" for the stepwise development of research instrumentation, clinical diagnosis instrumentation, and possibly clinical screening instrumentation. The specific aims of the Phase I is to develop and demonstrate: 1) Shortening the image acquisition time by using a higher power, higher energy X-ray source; 2) Implementing a sample scanning system to increase field of view; 3) Improving the mechanical stability of the system together with reducing the time for aligning the optical system. Assuming favorable results from phase I, the aims of the Phase II project will be the implementation of: a high-power (60 KW) X-ray source; of a more efficient detector; of a user-friendly GUI; of predictive modeling for simple systems, and of a means of relative image quality quantification.

描述（由申请人提供）：衍射增强成像（DEI）是一种新的X射线成像方法，具有彻底改变X射线医学成像的潜力，因为其在较低的X射线剂量下的对比度高于传统的放射摄影。DEI依赖于测量准直X射线束在采集图像时穿过对象（患者）时的微小角偏转。DEI在低密度矩阵中检测低密度特征的能力将使其在医学诊断和研究中特别有用。DEI目前仅限于同步辐射设施，但这项技术在医学成像研究中的潜在影响，以及随后在临床应用中的影响，将远远超过现有的或预计的同步辐射光束线的能力。我们建议开发用于医学成像研究的DEI实验室研究机。它的成功开发，以及可接受的图像采集时间、对比度和分辨率，将为随后的商业化提供必要的知识基础，这是DEI更广泛地使用和开发成像技术本身的关键，同时沿着适当的成像协议和方法的开发。因此，该项目将为逐步开发研究仪器、临床诊断仪器和可能的临床筛选仪器提供必要的“跳板技术”。第一阶段的具体目标是开发和演示：1）通过使用更高功率、更高能量的X射线源来缩短图像采集时间; 2）实现样品扫描系统以增加视场; 3）提高系统的机械稳定性，同时减少光学系统的对准时间。假设第一阶段的结果良好，第二阶段项目的目标将是实现：高功率（60千瓦）X射线源;更有效的探测器;用户友好的GUI;简单系统的预测建模，以及相对图像质量量化的手段。