Computational biomechanics to track bone vascular health and fracture risk.

用于跟踪骨血管健康和骨折风险的计算生物力学。

• 批准号: 2442607
• 金额: --
• 依托单位: University of Southampton
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2442607
• 关键词: Computational; biomechanics; track; bone; vascular

Bone adapts to mechanical loads by changing its overall geometry, microstructure and tissue properties such as degree of mineralisation. These functional bone adaptations are closely coupled to the bones' vascular health, maintaining overall bone strength and fracture resistance. There is an acknowledged divergence in age-related bone fracture risk between men and women. Demanding exercise regimes are known to compromise bone health in women including athletes. Further, sexual dimorphism in fracture risk has been reported in young active individuals, with lower limb fracture occurrence reported to be 3-fold higher in women than men during military training. This PhD studentship will utilise state-of-the-art imaging techniques and finite element modelling to assess bone microstructure and function following extreme exercise regimes used within the military and by athletes. This project offers a unique interdisciplinary programme at the engineering, life science, and biomedical interface with shared support from the Faculty of Engineering & Physical Sciences and the Faculty of the Environment and Life Sciences at the University of Southampton. The student will directly collaborate with researchers at the School of Biological Sciences and u-VIS X-ray Imaging Centre, while benefiting from the exceptional opportunity to gain expertise in cutting-edge bioimaging technologies, computational engineering approaches and our translational efforts to change the life for the better, based on engineering and biomedical expertise.

骨通过改变其整体几何形状、微观结构和组织特性（如矿化程度）来适应机械载荷。这些功能性骨骼适应与骨骼的血管健康密切相关，保持整体骨骼强度和抗骨折性。在与年龄相关的骨折风险方面，男性和女性之间存在着公认的差异。众所周知，要求严格的运动制度会损害女性（包括运动员）的骨骼健康。此外，据报道，在年轻的活跃个体中，骨折风险的性别二型性，据报道，在军事训练期间，女性下肢骨折的发生率比男性高3倍。该博士生将利用最先进的成像技术和有限元建模来评估军队和运动员使用的极端运动制度后的骨骼微观结构和功能。该项目在工程，生命科学和生物医学界面提供了一个独特的跨学科课程，并得到了南安普顿大学工程与物理科学学院和环境与生命科学学院的共同支持。学生将直接与生物科学学院和u-VIS X射线成像中心的研究人员合作，同时受益于获得尖端生物成像技术，计算工程方法和我们的翻译工作的专业知识的特殊机会。