Exercise intolerance and impaired glycaemic control in heart failure patients: Identifying microvascular dysfunction as a novel mechanism

心力衰竭患者的运动不耐受和血糖控制受损：将微血管功能障碍识别为一种新机制

• 批准号: nhmrc : GNT1157930
• 负责人: Dr Lewan Parker
• 金额: $ 32.72万
• 依托单位: Deakin University
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/exercise-intolerance-impaired-novel-mechanism/1349247
• 关键词: Exercise; intolerance; impaired; glycaemic; control

Exercise intolerance and poor glucose control greatly contribute to reduced quality of life and longevity in heart failure patients with preserved ejection fraction. However, current treatments are largely ineffective, a likely side effect of our poor understanding of the mechanisms behind this condition. This research will establish microvascular dysfunction, rather than heart dysfunction, as the underlying mechanism of poor health and will identify exercise as an effective treatment strategy.

运动不耐受和血糖控制不良极大地降低了射血分数保留的心力衰竭患者的生活质量和寿命。然而，目前的治疗方法在很大程度上是无效的，这可能是我们对这种情况背后的机制缺乏了解的副作用。这项研究将确立微血管功能障碍，而不是心脏功能障碍，作为健康不良的潜在机制，并将确定运动是一种有效的治疗策略。