Exercise intolerance and impaired glycaemic control in heart failure patients: Identifying microvascular dysfunction as a novel mechanism

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Exercise intolerance and poor glucose control greatly contribute to reduced quality of life and longevity in heart failure patients with preserved ejection fraction. However, current treatments are largely ineffective, a likely side effect of our poor understanding of the mechanisms behind this condition. This research will establish microvascular dysfunction, rather than heart dysfunction, as the underlying mechanism of poor health and will identify exercise as an effective treatment strategy.