Improving Exercise Capacity with a Tailored Physical Activity Intervention in Lymphoma Patients Undergoing Treatment

通过针对接受治疗的淋巴瘤患者进行量身定制的身体活动干预来提高运动能力

基本信息

项目摘要

Cardiovascular (CV) events related to the receipt of potentially cardiotoxic anthracycline-based chemotherapy (Anth-bC), are emerging as leading causes of morbidity and mortality for survivors of lymphoma (the 5th most common cancer in North America). The objective of our proposal is to reduce this cancer treatment related CV morbidity by developing, enabling, and testing a physical activity intervention that commences and continues throughout receipt of Anth-bC for the purpose of attenuating physical inactivity, preserving exercise capacity, CV & cognitive function, strength, and health-related quality of life (HRQOL) for those with lymphoma. The need for and the design of this program is based in part on feedback from lymphoma survivor focus groups treated in our NIH funded Comprehensive Cancer Center - preliminary pilot data (Section 3.C.1). Several novel features of this proposal include: 1) Performance of physical activity during receipt of cancer treatment where exercise intolerance originates. 2) Creation of patient communities that enable cancer patients to support one another during treatment. 3) Administration of aerobic & strength activities suited to one's individual lifestyle in the home guided by instruction provided from 4 close to home cardiac rehabilitation facilities experienced in exercising immunocompromised individuals and those with other pre-existing activity limitations due to cancer. 4) Utilization of newly developed magnetic resonance cardiopulmonary exercise treadmill testing methods to measure the two components (cardiac function and peripheral factors) that contribute to peak VO2 (a measure of maximal exercise capacity). This new information will provide mechanistic insight into how physical activity helps preserve exercise capacity and reduce fatigue. 5) Assessment of the relationships between cognitive function, activity, and exercise capacity thereby helping to unravel the association between physical activity, HRQOL and cognitive function in cancer patients. In this application, we propose to refine the physical activity intervention during the R21 Phase in patients who participate in the intervention for 6 months. If suitable milestones are achieved, we will conduct a randomized clinical trial in the R33 Phase to test the utility of the integrated physical activity intervention for sustaining peak V02, 6-min walk distance, cardiac and cognitive function, strength, activity, and HRQOL. If we achieve our study goals, this proposed intervention could reduce CV mortality and heart failure related hospital admissions, translate into clinical practice via extension through cardiac rehabilitation centers (often located close to cancer centers), increase health-related quality of life, reduce fatigue to perform activities of daily living, and attenuate cognitive function decline in lymphoma survivors. The results of this study could help to change existing sedentary behavior paradigms during receipt of chemotherapy and ultimately lead to improved long term outcomes for those with lymphoma and potentially other forms of cancer.
与接受潜在心脏毒性的蒽环类化疗相关的心血管(CV)事件 (Anth-bC),正在成为淋巴瘤幸存者发病率和死亡率的主要原因(第5届 北美最常见的癌症)。我们提案的目的是减少这种癌症治疗 通过开发、启用和测试一种体力活动干预措施, 在接受Anth-bC期间持续使用,以减少身体活动,保持锻炼 能力,CV和认知功能,强度,以及淋巴瘤患者的健康相关生活质量(HRQOL)。 该计划的需要和设计是基于部分从淋巴瘤幸存者焦点的反馈 在我们的NIH资助的综合癌症中心接受治疗的组-初步试验数据(第3.C.1节)。 该提案的若干新特点包括: 1)在接受癌症治疗期间进行身体活动,其中运动不耐受起源。 2)创建患者社区,使癌症患者在治疗期间相互支持。 3)管理有氧和力量活动适合一个人的个人生活方式在家里的指导下 从4家有锻炼经验的家庭心脏康复机构提供指导 免疫受损个体和由于癌症而具有其他预先存在的活动限制的那些。 4)利用新开发的磁共振心肺运动平板试验方法, 测量导致峰值VO 2(a)的两个分量(心功能和外周因素 最大运动能力(maximum exercise capacity)这一新信息将提供机械的洞察力, 体力活动有助于保持运动能力和减少疲劳。 5)评估认知功能、活动和运动能力之间的关系,从而帮助 阐明癌症患者体力活动、HRQOL和认知功能之间的关联。 在本申请中,我们建议在R21阶段对以下患者进行身体活动干预: 参与干预6个月。如果达到合适的里程碑,我们将进行随机化 R33阶段的临床试验,旨在测试综合体力活动干预对维持峰值的效用 V02、6分钟步行距离、心脏和认知功能、力量、活动和HRQOL。 如果我们实现了我们的研究目标,这种拟议的干预措施可以降低CV死亡率和心力衰竭相关性。 住院,通过心脏康复中心(通常 位于癌症中心附近),提高健康相关的生活质量,减少疲劳,以执行活动, 日常生活,并减弱淋巴瘤幸存者的认知功能下降。这项研究的结果可能有助于 在接受化疗期间改变现有的久坐行为模式,并最终导致 改善淋巴瘤和其他潜在癌症患者的长期预后。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

William Gregory Hundley其他文献

William Gregory Hundley的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('William Gregory Hundley', 18)}}的其他基金

Undergraduate Cardiovascular Research Program
本科心血管研究计划
  • 批准号:
    10361065
  • 财政年份:
    2022
  • 资助金额:
    $ 38.7万
  • 项目类别:
Undergraduate Cardiovascular Research Program
本科心血管研究计划
  • 批准号:
    10549810
  • 财政年份:
    2022
  • 资助金额:
    $ 38.7万
  • 项目类别:
Multi-Disciplinary Training Program in Translational Cardiovascular Research
转化心血管研究的多学科培训计划
  • 批准号:
    10583494
  • 财政年份:
    2020
  • 资助金额:
    $ 38.7万
  • 项目类别:
Multi-Disciplinary Training Program in Translational Cardiovascular Research
转化心血管研究的多学科培训计划
  • 批准号:
    10369689
  • 财政年份:
    2020
  • 资助金额:
    $ 38.7万
  • 项目类别:
Multi-Disciplinary Training Program in Translational Cardiovascular Research
转化心血管研究的多学科培训计划
  • 批准号:
    10117092
  • 财政年份:
    2020
  • 资助金额:
    $ 38.7万
  • 项目类别:
Improving Exercise Capacity with a Tailored Physical Activity Intervention in Lymphoma Patients Undergoing Treatment
通过针对接受治疗的淋巴瘤患者进行量身定制的身体活动干预来提高运动能力
  • 批准号:
    10705825
  • 财政年份:
    2018
  • 资助金额:
    $ 38.7万
  • 项目类别:
Understanding and Predicting Fatigue, CV Decline & Events After Breast CA Treatment
了解和预测疲劳、CV 下降
  • 批准号:
    9994850
  • 财政年份:
    2015
  • 资助金额:
    $ 38.7万
  • 项目类别:
Understanding and Predicting Fatigue, CV Decline & Events After Breast CA Treatment
了解和预测疲劳、CV 下降
  • 批准号:
    10481826
  • 财政年份:
    2015
  • 资助金额:
    $ 38.7万
  • 项目类别:
Understanding and Predicting Fatigue, CV Decline & Events After Breast CA Treatment
了解和预测疲劳、CV 下降
  • 批准号:
    9124809
  • 财政年份:
    2015
  • 资助金额:
    $ 38.7万
  • 项目类别:
Preventing Anthracycline Cardiovascular Toxicity with Statins
用他汀类药物预防蒽环类药物的心血管毒性
  • 批准号:
    8825555
  • 财政年份:
    2013
  • 资助金额:
    $ 38.7万
  • 项目类别:

相似海外基金

Pharmacy-led Transitions of Care Intervention to Address System-Level Barriers and Improve Medication Adherence in Socioeconomically Disadvantaged Populations
药房主导的护理干预转型,以解决系统层面的障碍并提高社会经济弱势群体的药物依从性
  • 批准号:
    10594350
  • 财政年份:
    2023
  • 资助金额:
    $ 38.7万
  • 项目类别:
Evaluating Centralizing Interventions to Address Low Adherence to Lung Cancer Screening Follow-up in Decentralized Settings
评估集中干预措施,以解决分散环境中肺癌筛查随访依从性低的问题
  • 批准号:
    10738120
  • 财政年份:
    2023
  • 资助金额:
    $ 38.7万
  • 项目类别:
Suubi-Mhealth: A mobile health intervention to address depression and improve ART adherence among Youth living with HIV (YLHIV) in Uganda
Suubi-Mhealth:一种移动健康干预措施,旨在解决乌干达艾滋病毒感染者 (YLHIV) 青少年的抑郁症问题并提高抗逆转录病毒疗法的依从性
  • 批准号:
    10526768
  • 财政年份:
    2022
  • 资助金额:
    $ 38.7万
  • 项目类别:
Suubi-Mhealth: A mobile health intervention to address depression and improve ART adherence among Youth living with HIV (YLHIV) in Uganda
Suubi-Mhealth:一种移动健康干预措施,旨在解决乌干达艾滋病毒感染者 (YLHIV) 青少年的抑郁症问题并提高抗逆转录病毒疗法的依从性
  • 批准号:
    10701072
  • 财政年份:
    2022
  • 资助金额:
    $ 38.7万
  • 项目类别:
A behavioral intervention for Black men who have sex with men and live with HIV to address intersectional stigma and improve antiretroviral therapy adherence
针对男男性行为且感染艾滋病毒的黑人男性进行行为干预,以解决交叉耻辱并提高抗逆转录病毒治疗的依从性
  • 批准号:
    10679092
  • 财政年份:
    2021
  • 资助金额:
    $ 38.7万
  • 项目类别:
A behavioral intervention for Black men who have sex with men and live with HIV to address intersectional stigma and improve antiretroviral therapy adherence
针对男男性行为且感染艾滋病毒的黑人男性进行行为干预,以解决交叉耻辱并提高抗逆转录病毒治疗的依从性
  • 批准号:
    10432133
  • 财政年份:
    2021
  • 资助金额:
    $ 38.7万
  • 项目类别:
A behavioral intervention for Black men who have sex with men and live with HIV to address intersectional stigma and improve antiretroviral therapy adherence
针对男男性行为且感染艾滋病毒的黑人男性进行行为干预,以解决交叉耻辱并提高抗逆转录病毒治疗的依从性
  • 批准号:
    10327065
  • 财政年份:
    2021
  • 资助金额:
    $ 38.7万
  • 项目类别:
Leveraging Technology to Address Access and Adherence to Conventional Hospital-Based Pulmonary Rehabilitation in Veterans with COPD
利用技术解决慢性阻塞性肺病退伍军人接受和坚持传统医院肺康复的问题
  • 批准号:
    10377366
  • 财政年份:
    2019
  • 资助金额:
    $ 38.7万
  • 项目类别:
Leveraging Technology to Address Access and Adherence to Conventional Hospital-Based Pulmonary Rehabilitation in Veterans with COPD
利用技术解决慢性阻塞性肺病退伍军人接受和坚持传统医院肺康复的问题
  • 批准号:
    10574496
  • 财政年份:
    2019
  • 资助金额:
    $ 38.7万
  • 项目类别:
Targeted interventions to address the multi-level effects of gender-based violence on PrEP uptake and adherence among adolescent girls and young women in Kenya
有针对性的干预措施,以解决性别暴力对肯尼亚少女和年轻妇女接受和坚持 PrEP 的多层面影响
  • 批准号:
    9403567
  • 财政年份:
    2017
  • 资助金额:
    $ 38.7万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了