Analytical Performance And Clinical Utility Of Thyroid F

甲状腺 F 的分析性能和临床实用性

• 批准号: 6825472
• 负责人: Gyorgy Csako
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6825472
• 关键词: cancer prevention; clinical trials; diagnosis design /evaluation; diagnostic tests; hemostasis; hormone regulation /control mechanism; hormone therapy; human subject; human therapy evaluation; lipids; meta analysis; neoplasm /cancer therapy; patient oriented research; thyroid function; thyroid neoplasm; thyroxine

Both hypothyroid and hyperthyroid patients have been reported to be associated with an increased incidence of atherothrombotic events. We completed analysis of thyroid function tests, serum lipid parameters (with special respect to lipoprotein[a]) and various hemostatic parameters in previously thyroidectomized patients who underwent thyroid scan for follow-up of their thyroid cancer. At that time, the patients change their thyroid status from hyperthyroid (due to thyroid hormone suppression therapy) to temporarily hypothyroid (due to discontinuation of thyroid hormone suppression therapy.) The blood specimens obtained during these phases represent primarily systemic thyroid hormone effects as opposed to underlying diseases with confounding effects of inflammation, etc., in primary hypothyroidism and hyperthyroidism. Since all previous studies compared different groups of hypothyroid and hyperthyroid patients, the results obtained in our studies with the same patients in different thyroid status are expected to provide a clearer understanding of the effect of thyroid hormones on components of atherothrombosis.

据报道，甲状腺功能减退和甲状腺功能亢进患者均与动脉粥样硬化血栓形成事件的发生率增加相关。我们完成了对既往接受甲状腺切除术患者的甲状腺功能检查、血脂参数（特别是脂蛋白[a]）和各种止血参数的分析，这些患者接受了甲状腺扫描以随访甲状腺癌。此时，患者的甲状腺状态从甲状腺功能亢进（由于甲状腺激素抑制治疗）变为暂时性甲状腺功能减退（由于停止甲状腺激素抑制治疗）。在这些阶段获得的血液样本主要代表全身性甲状腺激素效应，而不是具有炎症等混杂效应的基础疾病，原发性甲状腺功能减退症和甲状腺功能亢进症由于之前的所有研究都比较了不同甲状腺功能减退和甲状腺功能亢进患者组，因此我们对相同患者在不同甲状腺状态下的研究结果有望更清楚地了解甲状腺激素对动脉粥样硬化血栓形成成分的影响。