Analgesic Mechanisms In Patients With Chronic Pain

慢性疼痛患者的镇痛机制

• 批准号: 6814427
• 负责人: MITCHELL B MAX
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6814427
• 关键词: AMPA receptors; NMDA receptors; alternative medicine; amputation; analgesia; analgesics; behavioral genetics; chronic pain; clinical trials; combination chemotherapy; drug screening /evaluation; glutamate receptor; glutamates; human subject; human therapy evaluation; limbs; longitudinal human study; morphine; nerve injury; patient oriented research; pharmacokinetics; sciatica; shingles; temporomandibular joint syndrome; vertebrae

The purpose of this project is to elucidate the neural mechanisms and principles of treatment of chronic pain syndromes. We are conducting clinical trials of single drugs, drug combinations, and alternative medicine techniques in chronic lumbar radiculopathy pain. A new program in pain genetics has localized a gene affecting pain behaviors to a small region of one chromosome containing several genes whose gene products have previously been linked to pain processing. Candidate gene studies are beginning in a cohort of 500 patients with 10-year followup of sciatica in the Maine Lumbar Spine Study, and with cohorts of patients with other neuropathic pain disorders and temporomandibular disorder.

该项目的目的是阐明慢性疼痛综合征治疗的神经机制和原理。我们正在进行慢性腰椎疼痛中的单一药物，药物组合和替代医学技术的临床试验。一个新的疼痛遗传学程序将影响疼痛行为的基因定位在一个染色体的一小部分，其中包含几种基因产物以前与疼痛处理有关的基因。候选基因研究始于500例在缅因州腰椎研究中进行10年坐骨神经痛的患者，并与其他神经性疼痛障碍和颞下颌疾病的患者同类。