Exercise reverses cognitive decline in aged animals by growth hormone stimulation of neurogenesis in the hippocampus

运动通过生长激素刺激海马神经发生逆转老年动物的认知能力下降

• 批准号: nhmrc : GNT1130141
• 负责人: Dr Daniel Blackmore
• 金额: $ 69.64万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/exercise-reverses-cognitive-neurogenesis-hippocampus/1347794
• 关键词: Exercise; reverses; cognitive; decline; aged

The production of new neurons in the hippocampus plays a critical role in learning and memory. With increasing age, this production slows and is associated with cognitive decline. However the stem cells that make new neurons are still present, and we have discovered that exercise activates these cells, leading to renewed neuron production and reversal of cognitive decline. We will explore how this process is regulated in order to develop strategies to reduce cognitive decline in humans.

海马区新神经元的产生对学习和记忆起着至关重要的作用。随着年龄的增长，这种产生会减慢，并与认知能力下降有关。然而，制造新神经元的干细胞仍然存在，我们发现运动激活了这些细胞，导致新的神经元产生和认知衰退的逆转。我们将探索这一过程是如何被调控的，以便开发出减少人类认知衰退的策略。