Stimulation of neurogenesis by growth hormone to improve cognition in an aged animal model of dementia

通过生长激素刺激神经发生来改善老年痴呆动物模型的认知能力

• 批准号: nhmrc : 1067909
• 负责人: Dr Daniel Blackmore
• 金额: $ 36.73万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/stimulation-neurogenesis-growth-model-dementia/455325
• 关键词: Stimulation; neurogenesis; growth; hormone; improve

Production of new neurons in the hippocampus of adult animals plays a role in regulating learning and memory, and this production slows continuously with increasing age. Here we explore ways to activate dormant populations of neurogenic precursor cells in the hippocampus to produce new neurons. Since the precursor cells are still present in the hippocampus of an aged animal these studies will provide unequivocal evidence for their importance in reversing age-related cognitive decline and dementia.

成年动物海马中新神经元的产生在调节学习和记忆中起作用，随着年龄的增长，新神经元的产生不断减缓。在这里，我们探索激活海马体中休眠的神经原性前体细胞群以产生新神经元的方法。由于前体细胞仍然存在于老年动物的海马体中，这些研究将为它们在逆转与年龄相关的认知能力下降和痴呆方面的重要性提供明确的证据。