International Meeting on Gonadotropins

简介（由申请人提供）：2004年秋季将在乔治亚大学乔治亚中心召开一次关于促性腺激素（异二聚体糖蛋白激素）、其G蛋白偶联受体和新的临床诊断应用的国际会议。本次会议的目的是回顾自1996年上次会议以来该领域的进展，并根据最近的发现为正确开发新的诊断应用提出一些共识建议。令人兴奋的新进展包括激素及其受体的结构-功能关系的知识进展，这些发现与临床观察的相关性，促性腺激素的新功能，特别是hCG，除了生殖生理学的经典功能之外，以及对促性腺激素的命名，单位和临床实验室测量的更好的可比性的建议的发展。主题将包括：促性腺激素及其受体的结构功能研究、信号转导、与促性腺激素相关的孤儿受体、促性腺激素及其异构体的测量、通过新标准和单位改进的临床检测相关性、hCG异构体测量在产前诊断和癌症诊断和治疗中的新临床应用。会议将吸引来自学术机构、联邦实验室和制药公司的科学家和受训人员，以及医学界以研究/诊断为导向的成员。组委会由一个活跃在促性腺激素领域的国际科学家小组组成，其中包括一些来自诊断试剂盒制造商的研究人员，以便基础研究进展能够迅速转化为临床应用，造福社会。由会议上的发言者和其他选定与会者撰写的同行评议论文组成的专著已与该领域的知名出版商安排出版。

DESCRIPTION (provided by applicant): An international conference is proposed to be held at the Georgia Center at the University of Georgia in the Fall 2004 on gonadotropins (heterodimeric glycoprotein hormones), their G protein-coupled receptors, and novel clinical diagnostic applications. The goals of this meeting are to review the progress in this field since the last such meeting in 1996 and to develop some consensus recommendations for proper development of new diagnostic applications deriving from recent discoveries. Exciting new developments include advances in knowledge of the structure-function relationships of the hormones and their receptors, correlation of these discoveries with clinical observations, novel functions of the gonadotropins, especially hCG, in additional to classical functions in reproductive physiology, and development of recommendations for nomenclature, unitage, and better comparability for clinical laboratory measurements of the gonadotropins. Topics will include: structure function studies of the gonadotropins and their receptors, signal transduction, orphan receptors related to gonadotropins, measurement of gonadotropins and their isoforms, improved clinical assay correlations through new standards and units, novel clinical applications of measurement of hCG isoforms in prenatal diagnosis and cancer diagnosis and treatment. The meeting will attract scientists and trainees from academic institutions, federal laboratories, and pharmaceutical firms, as well as research/diagnostic oriented members of the medical community. The organizing committee is comprised of an international group of scientists active in the gonadotropin field and includes some investigators from diagnostic kit manufacturers as well so that basic research progress can be rapidly translated into clinical applications for the general benefit of society. Publication of a monograph comprised of peer-reviewed papers written by speakers and other selected attendees at the meeting has been arranged with an established publisher in the field.