"Nicotine: Potential therapies and possible pitfalls"

“尼古丁：潜在的疗法和可能的陷阱”

• 批准号: 6808063
• 负责人: RUSSELL WAYNE BROWN
• 金额: $ 2.4万
• 依托单位: EAST TENNESSEE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-06-07 至 2004-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6808063
• 关键词: cognitive behavior therapy; meeting /conference /symposium; neurosciences; nicotine; travel

DESCRIPTION (provided by applicant): The purpose of this proposal is to request funds to support a one day satellite symposium entitled "Nicotine: Potential therapies and possible pitfalls" to the 2004 International Behavioral Neuroscience Society (IBNS) Conference in Key West, FL. The dates for this meeting are from June 16th to June 20th, 2004. The recent and exciting developments in nicotine research represent a specific need for this symposium. Although there have been several other symposia focused on nicotine over the past few years, most of these have focused on a specific research area, such as nicotine as an addictive drug or on its effects relative to a specific behavioral disorder or neurodegenerative disease. The proposed symposium is designed to convene experts from across the diverse areas of nicotine research to identify nicotine's therapeutic potential, the possible pitfalls of utilizing nicotine as a therapeutic agent, and potential mechanisms of action. A primary goal for this meeting is to encourage discussion amongst scientists from diverse research backgrounds and with wide-ranging interests that can reveal commonalities of approach regarding nicotine as a potential therapy, as well as the positive and negative consequences of nicotine administration in a variety of behavioral, cognitive and neurological research models. However, because nicotine is a psychostimulant, the psychoactive ingredient in tobacco and believed to be the primary ingredient responsible for nicotine addiction, there are obvious potential pitfalls to using nicotine as a therapeutic agent. On the other hand, nicotine and agonists to the acetylcholinergic nicotinic receptor have been shown to eliminate anxiety when given at low doses, enhance cognition, and to significantly reduce, or even eliminate cognitive deficits produced by brain injury and sensory deficits in schizophrenics. Nicotine also increases neurotrophic factor expression and this effect of the drug may have an important role in neuroprotection in neurodegenerative disorders such as Alzheimer's and Parkinson's disease. Therefore, several topics across this field will be covered, including underlying mechanisms of nicotine addiction, the role of the nicotinic receptor in behavior and neuroprotection, nicotine's potential therapeutic effects in Alzheimer's and Parkinson's disease, nicotine's role in anxiety, and it's effects on behavior in schizophrenia and brain trauma in animal models as well as humans. The symposium is also designed to bring together a group of scientists at all career levels including graduate students, post-doctoral fellows, assistant, associate, and full professors. In doing this we hope to provide a stimulating environment for the more senior researchers and a nurturing environment for the more junior participants. Additionally, the scientific background of these scientists is also very diverse. The research disciplines of the invitees to the symposium range from molecular neuroscience to behavioral neuroscience and neurology that also work with a variety of species, ranging from rodent to primate to human. Although speakers and session leaders will provide an introduction suited for the less acquainted attendee, presentations will be geared to late-breaking, novel and often unpublished findings to bring as many people to the forefront of the field as possible. In addition to the organizers, eleven scientists have accepted invitations to this symposium, and each will present their latest research in a 30-minute talk. Additionally, we plan a final roundtable discussion with all speakers to discuss the commonalities of the positive effects, underlying mechanisms, and adverse effects of nicotine as a potential therapy.

描述（由申请人提供）： 本提案的目的是申请资金，以支持在佛罗里达州基韦斯特举行的2004年国际行为神经科学学会（IBNS）会议的为期一天的题为“尼古丁：潜在的治疗方法和可能的陷阱”的卫星研讨会。尼古丁研究的最新和令人兴奋的发展代表了对这次研讨会的特殊需要。虽然在过去几年中有几个其他研讨会关注尼古丁，但大多数都集中在特定的研究领域，例如尼古丁作为成瘾药物或其对特定行为障碍或神经退行性疾病的影响。拟议的研讨会旨在召集来自尼古丁研究各个领域的专家，以确定尼古丁的治疗潜力，利用尼古丁作为治疗剂的可能陷阱以及潜在的作用机制。本次会议的主要目标是鼓励来自不同研究背景和广泛兴趣的科学家进行讨论，以揭示尼古丁作为潜在疗法的方法的共性，以及尼古丁给药在各种行为，认知和神经学研究模型中的积极和消极后果。 然而，由于尼古丁是一种精神兴奋剂，是烟草中的精神活性成分，被认为是尼古丁成瘾的主要成分，因此使用尼古丁作为治疗剂存在明显的潜在陷阱。另一方面，尼古丁和乙酰胆碱能烟碱受体激动剂在低剂量给药时可消除焦虑，增强认知，并显著减少甚至消除精神分裂症患者脑损伤和感觉缺陷引起的认知缺陷。尼古丁还增加神经营养因子的表达，药物的这种作用可能在神经退行性疾病如阿尔茨海默病和帕金森病的神经保护中起重要作用。因此，将涵盖该领域的几个主题，包括尼古丁成瘾的潜在机制，尼古丁受体在行为和神经保护中的作用，尼古丁在阿尔茨海默病和帕金森病中的潜在治疗作用，尼古丁在焦虑中的作用，以及它对精神分裂症和动物模型以及人类脑创伤行为的影响。 研讨会还旨在汇集一组科学家在所有职业水平，包括研究生，博士后研究员，助理，副教授和正教授。在这样做的时候，我们希望为更资深的研究人员提供一个激励的环境，为更初级的参与者提供一个培养的环境。此外，这些科学家的科学背景也非常多样化。研讨会受邀者的研究学科范围从分子神经科学到行为神经科学和神经学，也与各种物种合作，从啮齿动物到灵长类动物再到人类。虽然演讲者和会议负责人将提供适合不太熟悉的与会者的介绍，但演讲将针对最新的，新颖的，通常未发表的发现，以使尽可能多的人走到该领域的最前沿。除了组织者之外，还有11位科学家接受了这次研讨会的邀请，每人将在30分钟的演讲中介绍他们的最新研究。此外，我们计划与所有发言者进行最后的圆桌讨论，讨论尼古丁作为一种潜在疗法的积极作用、潜在机制和不良反应的共性。