FASEB Summer Conference on Neuroimmunology

FASEB 神经免疫学夏季会议

• 批准号: 6808689
• 负责人: Doina Ganea
• 金额: $ 2.5万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-06-01 至 2004-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6808689
• 关键词: antigen presenting cell; brain injury; central nervous system; inflammation; meeting /conference /symposium; neural degeneration; neuroimmunomodulation; travel

DESCRIPTION (provided by applicant): This application is a request for support for the 8th FASEB Neuroimmunology Summer Research Conference to be held in Tucson, AZ, August 7-12, 2004. In the last decade, scientists from different disciplines became interested in the cross talk between the immune and nervous system. Accumulating evidence suggests that immune factors and cells play a role in the CNS in normal and pathological conditions, and that the CNS regulates peripheral immune responses. Rapid advances make it necessary to reassess a number of basic aspects of CNS-immune interactions, including anatomical, physiological, and functional aspects. Previously, interest in the immune involvement in the CNS was limited to brain autoimmune diseases. However, CNS trauma and neurodegenerative diseases are recognized today as having inflammatory components. Examples include Alzheimer's disease, HIV associated dementia, Parkinson's disease, brain trauma, and spinal cord injury. On the other hand, several CNS products downregulate peripheral immunity, having a beneficial effect on pathological conditions such as septic shock and autoimmune diseases. This alters our view of therapeutic approaches for the treatment of both autoimmune and neurodegenerative diseases. At the 2004 FASEB meeting, we plan to expand on basic issues regarding the role of immune mediators in CNS inflammation and neuroprotection, on the immunomodulatory role of CNS products, and on the molecular mechanisms related to immune cell CNS trafficking and the functional establishment of the immune privileged sites. Questions will be raised regarding the origin and function of CNS antigen presenting cells, viral targeting of the CNS, beneficial and detrimental effects of CNS autoimmunity. Finally, a major thrust of this conference will be to explore the role and mechanisms of inflammation in CNS trauma and neurodegenerative diseases. This meeting provides a much needed platform for scientific discussions in both basic and clinical neuroimmunology.

描述（由申请人提供）：本申请是对将于2004年8月7日至12日在亚利桑那州图森市举行的第八届FASEB神经免疫学夏季研究会议的支持请求。在过去的十年里，来自不同学科的科学家对免疫系统和神经系统之间的相互作用产生了兴趣。越来越多的证据表明，免疫因子和细胞在正常和病理条件下在CNS中发挥作用，并且CNS调节外周免疫应答。快速的进步使得有必要重新评估CNS-免疫相互作用的一些基本方面，包括解剖学，生理学和功能方面。以前，对CNS中免疫参与的兴趣仅限于脑自身免疫性疾病。然而，CNS创伤和神经退行性疾病今天被认为具有炎症成分。例子包括阿尔茨海默病、HIV相关痴呆、帕金森病、脑外伤和脊髓损伤。另一方面，几种CNS产品下调外周免疫，对病理状况如感染性休克和自身免疫性疾病具有有益作用。这改变了我们对治疗自身免疫性疾病和神经退行性疾病的治疗方法的看法。在2004年FASEB会议上，我们计划扩大对免疫介质在中枢神经系统炎症和神经保护中的作用，对中枢神经系统产品的免疫调节作用，以及对免疫细胞中枢神经系统运输和免疫特权网站的功能建立相关的分子机制的基本问题。关于CNS抗原呈递细胞的起源和功能，CNS的病毒靶向，CNS自身免疫的有益和有害作用的问题将被提出。最后，本次会议的一个主要目标将是探讨炎症在中枢神经系统创伤和神经退行性疾病中的作用和机制。这次会议为基础和临床神经免疫学的科学讨论提供了一个急需的平台。