FASEB Summer Conference on Neuroimmunology

描述(由申请人提供)：本申请是对将于2004年8月7日至12日在亚利桑那州图森举行的第8届FASE B神经免疫学夏季研究会议的支持申请。在过去的十年里，来自不同学科的科学家对免疫系统和神经系统之间的相互作用产生了兴趣。越来越多的证据表明，在正常和病理条件下，免疫因子和细胞在中枢神经系统中发挥作用，中枢神经系统调节外周免疫反应。快速的发展使得有必要重新评估中枢神经系统免疫相互作用的一些基本方面，包括解剖学、生理学和功能方面。此前，对中枢神经系统免疫参与的兴趣仅限于脑自身免疫性疾病。然而，中枢神经系统创伤和神经退行性疾病今天被认为是有炎症成分的。例如阿尔茨海默氏症、艾滋病毒相关性痴呆症、帕金森氏症、脑创伤和脊髓损伤。另一方面，几种中枢神经系统产品下调外周免疫功能，对感染性休克和自身免疫性疾病等病理条件有有益影响。这改变了我们对治疗自身免疫性和神经退行性疾病的治疗方法的看法。在2004年的FASE B会议上，我们计划就免疫介质在中枢神经系统炎症和神经保护中的作用、中枢神经系统产品的免疫调节作用、与免疫细胞中枢神经系统运输和免疫特权部位的功能建立有关的分子机制等基本问题展开讨论。将提出关于中枢神经系统抗原提呈细胞的起源和功能、中枢神经系统的病毒靶向、中枢神经系统自身免疫的有益和有害影响等问题。最后，本次会议的主要主题将是探讨炎症在中枢神经系统创伤和神经退行性疾病中的作用和机制。这次会议为基础和临床神经免疫学的科学讨论提供了一个亟需的平台。

DESCRIPTION (provided by applicant): This application is a request for support for the 8th FASEB Neuroimmunology Summer Research Conference to be held in Tucson, AZ, August 7-12, 2004. In the last decade, scientists from different disciplines became interested in the cross talk between the immune and nervous system. Accumulating evidence suggests that immune factors and cells play a role in the CNS in normal and pathological conditions, and that the CNS regulates peripheral immune responses. Rapid advances make it necessary to reassess a number of basic aspects of CNS-immune interactions, including anatomical, physiological, and functional aspects. Previously, interest in the immune involvement in the CNS was limited to brain autoimmune diseases. However, CNS trauma and neurodegenerative diseases are recognized today as having inflammatory components. Examples include Alzheimer's disease, HIV associated dementia, Parkinson's disease, brain trauma, and spinal cord injury. On the other hand, several CNS products downregulate peripheral immunity, having a beneficial effect on pathological conditions such as septic shock and autoimmune diseases. This alters our view of therapeutic approaches for the treatment of both autoimmune and neurodegenerative diseases. At the 2004 FASEB meeting, we plan to expand on basic issues regarding the role of immune mediators in CNS inflammation and neuroprotection, on the immunomodulatory role of CNS products, and on the molecular mechanisms related to immune cell CNS trafficking and the functional establishment of the immune privileged sites. Questions will be raised regarding the origin and function of CNS antigen presenting cells, viral targeting of the CNS, beneficial and detrimental effects of CNS autoimmunity. Finally, a major thrust of this conference will be to explore the role and mechanisms of inflammation in CNS trauma and neurodegenerative diseases. This meeting provides a much needed platform for scientific discussions in both basic and clinical neuroimmunology.