Gordon Research Conference on Basement Membranes

戈登地下室膜研究会议

• 批准号: 6754259
• 负责人: JAMES M KRAMER
• 金额: $ 1.05万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-05-01 至 2005-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6754259
• 关键词: basement membrane; embryogenesis; extracellular matrix; invertebrate embryology; meeting /conference /symposium; membrane activity; membrane reconstitution /synthesis; membrane structure; travel; vertebrate embryology

DESCRIPTION (provided by applicant): This application requests partial funding for the support of invited speakers for the 2004 Gordon Conference on Basement Membranes. This is the twelfth in a highly successful series of conferences which are a major international forum for dissemination of new ideas and information about the structures and functions of basement membranes (BMs). These are complex, three-dimensional, extracellular structures formed at epithelial-mesenchymal interfaces and around mesenchymal cells, with important roles in the organization and function of most tissues and organs, e.g., muscle, skin, blood vessels, heart, lung, kidney, and peripheral nerves. For example, basement membranes regulate the migration and organization of ceils in the musculoskeletal system, as well as axons and synapses in the nervous system. Mutations in genes encoding basement membrane components result in severe inherited disorders in humans (e.g. epidermolysis bullosa of skin, congenital muscular dystrophies with associated neural defects, Alport syndrome of kidney). Acquired defects in basement membranes also contribute to the pathogenesis of diabetic microvascular disease and serve as entry sites for infectious agents, such as leprosy, and for metastatic cancer cells. Traditionally, the conference has attracted scientists from a wide range of fields in basic research, including protein and carbohydrate structure, gene expression, cell and developmental biology, and neurobiology. In addition, it has been attended by clinicians and scientists involved in research and/or treatment of human disorders involving BM components of lung, blood vessels, skin, kidney, bone, muscle and immune systems. Basic studies of BM degradation and turnover are also of interest to scientists investigating dynamic processes such as angiogenesis, cancer metastasis, embryo implantation, and involution of the mammary gland and uterus. There has been substantial interest from clinicians and scientists in the pharmaceutical and biotechnology industries studying the roles of BMs in wound healing, angiogenesis, nerve regeneration, inflammation, and tissue repair. The Conference will present a diverse mixture of sessions on the basic science of basement membrane and extracellular matrix (ECM) structure, biosynthesis, assembly, turnover, and functions. Comparative studies of BM function in vertebrates and invertebrates, and the roles of BM and ECM in embryonic development and embryonic stem cells will be included. In addition, emphasis will be given to studies on the genetic analyses of BM and ECM functions, and the generation of animal models of human BM disorders.

描述(由申请人提供)： 这项申请要求提供部分资金，以支持2004年戈登基底膜会议的特邀发言者。这是一系列非常成功的会议中的第十二次，这些会议是传播有关基底膜(BMS)结构和功能的新思想和信息的主要国际论坛。这些是复杂的三维细胞外结构，形成于上皮-间充质界面和间充质细胞周围，在大多数组织和器官的组织和功能中发挥重要作用，例如肌肉、皮肤、血管、心脏、肺、肾和周围神经。例如，基底膜调节肌肉骨骼系统中细胞的迁移和组织，以及神经系统中的轴突和突触。基底膜成分编码基因的突变会导致人类严重的遗传性疾病(例如皮肤大疱性表皮松解症、先天性肌营养不良伴相关的神经缺陷、肾脏的Alport综合征)。基底膜的获得性缺陷也有助于糖尿病微血管疾病的发病，并成为麻风病等感染性病原体和转移癌细胞的进入部位。传统上，这次会议吸引了来自基础研究领域广泛领域的科学家，包括蛋白质和碳水化合物结构、基因表达、细胞和发育生物学以及神经生物学。此外，参与研究和/或治疗人类疾病的临床医生和科学家也参加了会议，这些疾病涉及肺、血管、皮肤、肾脏、骨骼、肌肉和免疫系统的骨髓成分。BM降解和周转的基础研究也引起了科学家的兴趣，他们研究的动态过程包括血管生成、癌症转移、胚胎植入以及乳腺和子宫的退化。临床医生和制药和生物技术行业的科学家对BMS在伤口愈合、血管生成、神经再生、炎症和组织修复中的作用进行了大量的研究。会议将提供关于基底膜和细胞外基质(ECM)结构、生物合成、组装、周转和功能的基础科学的多样化混合会议。内容包括脊椎动物和无脊椎动物BM功能的比较研究，以及BM和ECM在胚胎发育和胚胎干细胞中的作用。此外，还将重点研究骨髓和细胞外基质功能的遗传分析，以及人类骨髓疾病动物模型的建立。