Pathogenic Mechanisms of Fibrosis:Common Ground

纤维化的致病机制：共同点

• 批准号: 6777954
• 负责人: ARNOLD E POSTLETHWAITE
• 金额: $ 2万
• 依托单位: UNIVERSITY OF TENNESSEE HEALTH SCI CTR
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-16 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6777954
• 关键词: fibrosis; meeting /conference /symposium; pathologic process; travel

DESCRIPTION (provided by applicant): We propose to hold a scientific meeting entitled "Pathogenic Mechanisms of Fibrosis: Search for Common Ground" on April 22-23, 2004 in Memphis, TN. The meeting will take place at the Fogelman Conference Center at the University of Memphis, Memphis, TN and will be jointly sponsored by the University of Tennessee, Memphis, the NIH and Industry. Participants in the meeting will include internationally recognized leaders and experts in the field of fibrosis. Both MD and PhD investigators will be included to provide cross-fertilization of basic science approaches to the understanding of clinically relevant problems. The primary focus will be on common mechanisms and pathways of fibrosis. The focus of this symposium will not be organ specific as is the case with many previous symposia that addresses fibrosis. Fibrosis is a feature of several arthritic, musculoskeletal and skin diseases such as systemic lupus, erythematosus, rheumatoid arthritis, systemic sclerosis (scleroderma) and morphea. This symposium addresses important topics related to the NtAMS mission. Exciting developments in research in the area of myofibroblast/fibroblast progenitors, novel modulation of myofibroblasts and genetic influence on fibrosis have occurred in the past few years that no doubt will move the field of fibrosis research and novel antifibrotic therapies forward at an accelerated rate. It is the goal of this symposium to facilitate the pace of fibrosis research by bringing together experts to review these new developments in a single forum. The program will specifically address 1) Progenitor Cell Transdifferentiation to Myofibroblasts, 2) Myofibroblast Phenotypic Characteristics and Mediators, 3) Genetics and Fibrosis and, 4) Potential Targets for Treating Fibrosis. Divergent views on these subjects have developed in different laboratories and in different parts of the world. This meeting will address some of those differences and provide a forum for developing new approaches and collaborations. Young investigator travel awards are being provided to encourage involvement of trainees and other young investigators.

描述（由申请人提供）： 我们建议于2004年4月22-23日在田纳西州的孟菲斯举行一次题为“纤维化的致病机制：寻找共同点”的科学会议。会议将在田纳西州孟菲斯的孟菲斯大学的福格尔曼会议中心举行，并将由田纳西大学孟菲斯、NIH和工业界联合主办。与会者将包括国际公认的纤维化领域的领导者和专家。医学博士和博士研究人员将被包括在内，以提供基础科学方法的交叉施肥，以了解临床相关问题。主要关注纤维化的常见机制和途径。这次研讨会的重点将不像以前的许多讨论纤维化的研讨会那样是器官特异性的。 纤维化是几种关节炎、肌肉骨骼和皮肤疾病的特征，如系统性狼疮、红斑狼疮、类风湿性关节炎、系统性硬化症（硬皮病）和硬斑病。本次研讨会讨论了与NtAMS使命有关的重要主题。过去几年，肌成纤维细胞/成纤维细胞祖细胞、肌成纤维细胞的新型调节和对纤维化的遗传影响领域的研究取得了令人兴奋的进展，这无疑将加速推动纤维化研究和新型抗纤维化疗法领域的发展。本次研讨会的目标是通过汇集专家在一个论坛上回顾这些新的发展来促进纤维化研究的步伐。该计划将专门解决1）祖细胞转分化为肌成纤维细胞，2）肌成纤维细胞表型特征和介体，3）遗传学和纤维化，4）治疗纤维化的潜在靶点。在不同的实验室和世界不同的地方，对这些问题产生了不同的看法。本次会议将讨论其中一些分歧，并为制定新的方法和开展合作提供一个论坛。正在提供青年调查员旅费奖励，以鼓励受训人员和其他青年调查员参与。