The 6th Annual Midwest DNA Repair Symposium

第六届年度中西部 DNA 修复研讨会

• 批准号: 6812855
• 负责人: ISABEL W MELLON
• 金额: $ 0.2万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-01 至 2005-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6812855
• 关键词: DNA repair; meeting /conference /symposium; travel

DESCRIPTION (provided by applicant) Individuals are continually exposed to a plethora of DNA damaging agents formed cells or within present in the environment. To combat the harmful effects, cells possess an assortment of DNA repair pathways that recognize and remove damaged DNA. These include nucleotide excision repair, transcription-coupled repair, mismatch repair and recombinational repair mechanisms. In addition, there are DNA polymerase lesion bypass mechanisms and signal transduction pathways that help cells tolerate DNA damage. It is clear that disruptions in DNA repair pathways can impact human disease states and multiple repair pathways help protect cells and Individuals from environmental insult. The overall goal of the 6th Annual Midwest DNA Repair Symposium is to disseminate and stimulate current through on basic and applied mechanisms of DNA repair and their impact on human disease states. It has three specific goals. One goal is to gather scientists in the field of DNA repair for presentations and discussions of current research in the field. The second goal is to expose any students and postdoctoral fellows in the field to current work. The third is to foster scientific interactions and stimulate new and ongoing collaborations. This has been a successful Symposium in the past five years. The impetus has been that while there are other small conferences such as Gordon conferences that are generally held on either the east or west coasts or in Europe, this Symposium provides a forum to gather independent investigators and their students and postdoctoral fellows that are located in the midwest. The 6th Annual DNA Repair Symposium will largely follow formats that have been successfully used in the past. There will be two keynote speakers, three platform sessions and on poster session. The speakers in the platform sessions will be largely chosen from the submitted abstracts. The University of Kentucky is well suited to be the host of this symposium. It has assembled a core of individuals (faculty) that are focused on the investigation of mechanisms of DNA repair.

描述（由申请人提供） 人们不断地暴露于细胞中或环境中存在的大量 DNA 损伤剂中。 为了对抗有害影响，细胞拥有多种 DNA 修复途径，可以识别并去除受损的 DNA。 这些包括核苷酸切除修复、转录偶联修复、错配修复和重组修复机制。 此外，还有DNA聚合酶损伤旁路机制和信号转导途径，帮助细胞耐受DNA损伤。 很明显，DNA 修复途径的破坏会影响人类疾病状态，多种修复途径有助于保护细胞和个人免受环境侵害。 第六届年度中西部 DNA 修复研讨会的总体目标是通过 DNA 修复的基本和应用机制及其对人类疾病状态的影响来传播和激发电流。 它有三个具体目标。 目标之一是聚集 DNA 修复领域的科学家来演示和讨论该领域的当前研究。 第二个目标是让该领域的所有学生和博士后研究员接触当前的工作。 第三是促进科学互动并刺激新的和持续的合作。 这是过去五年来一次成功的研讨会。 其推动力是，虽然其他小型会议（例如戈登会议）通常在东海岸或西海岸或欧洲举行，但本次研讨会提供了一个论坛来聚集位于中西部的独立研究人员及其学生和博士后研究员。 第六届年度 DNA 修复研讨会将主要遵循过去成功使用的形式。 将有两名主讲人、三场平台会议和海报会议。 平台会议的演讲者将主要从提交的摘要中选出。 肯塔基大学非常适合主办本次研讨会。 它聚集了一个核心人员（教员），专注于 DNA 修复机制的研究。