The 6th Annual Midwest DNA Repair Symposium

描述(由申请人提供) 个体不断地暴露在过多的DNA损伤剂中，形成细胞或存在于环境中。为了对抗有害影响，细胞拥有一系列DNA修复途径，可以识别和移除受损的DNA。这些机制包括核苷酸切除修复、转录偶联修复、错配修复和重组修复机制。此外，还有DNA聚合酶损伤旁路机制和信号转导途径，帮助细胞耐受DNA损伤。很明显，DNA修复途径的中断会影响人类的疾病状态，而多条修复途径有助于保护细胞和个人免受环境的侮辱。第六届中西部DNA修复研讨会的总体目标是传播和促进有关DNA修复的基本和应用机制及其对人类疾病状态的影响的最新进展。它有三个具体目标。其中一个目标是召集DNA修复领域的科学家介绍和讨论该领域的当前研究。第二个目标是让该领域的任何学生和博士后研究员接触到当前的工作。第三是促进科学互动，促进新的和正在进行的合作。这是过去五年来的一次成功的研讨会。推动力是，虽然还有其他小型会议，如戈登会议，通常在东西海岸或欧洲举行，但这次研讨会提供了一个论坛，让位于中西部的独立研究人员及其学生和博士后研究员聚集在一起。第六届年度DNA修复研讨会将在很大程度上遵循过去成功使用的模式。将有两位主旨演讲者、三次平台会议和海报会议。平台会议的发言者将主要从提交的摘要中选出。肯塔基大学非常适合主办这次研讨会。它聚集了一个核心的个人(教员)，他们专注于DNA修复机制的研究。

DESCRIPTION (provided by applicant) Individuals are continually exposed to a plethora of DNA damaging agents formed cells or within present in the environment. To combat the harmful effects, cells possess an assortment of DNA repair pathways that recognize and remove damaged DNA. These include nucleotide excision repair, transcription-coupled repair, mismatch repair and recombinational repair mechanisms. In addition, there are DNA polymerase lesion bypass mechanisms and signal transduction pathways that help cells tolerate DNA damage. It is clear that disruptions in DNA repair pathways can impact human disease states and multiple repair pathways help protect cells and Individuals from environmental insult. The overall goal of the 6th Annual Midwest DNA Repair Symposium is to disseminate and stimulate current through on basic and applied mechanisms of DNA repair and their impact on human disease states. It has three specific goals. One goal is to gather scientists in the field of DNA repair for presentations and discussions of current research in the field. The second goal is to expose any students and postdoctoral fellows in the field to current work. The third is to foster scientific interactions and stimulate new and ongoing collaborations. This has been a successful Symposium in the past five years. The impetus has been that while there are other small conferences such as Gordon conferences that are generally held on either the east or west coasts or in Europe, this Symposium provides a forum to gather independent investigators and their students and postdoctoral fellows that are located in the midwest. The 6th Annual DNA Repair Symposium will largely follow formats that have been successfully used in the past. There will be two keynote speakers, three platform sessions and on poster session. The speakers in the platform sessions will be largely chosen from the submitted abstracts. The University of Kentucky is well suited to be the host of this symposium. It has assembled a core of individuals (faculty) that are focused on the investigation of mechanisms of DNA repair.