Mechanistic dissection of interplay between membrane traffic and apoptosis by mutations in the endosomal sorting regulatory protein Vps45.

通过内体分选调节蛋白 Vps45 突变对膜运输和细胞凋亡之间相互作用的机制剖析。

• 批准号: 2444197
• 金额: --
• 依托单位: University of York
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2444197
• 关键词: Mechanistic; dissection; interplay; between; membrane

Eukaryotic cells have to coordinate a large number of cellular processes inorder to function properly. Understanding how this is achieved is critical formany areas of the biosciences. The protein Vps45 regulates membranetraffic through the endosomal system and also plays a role in preventing cellsfrom entering programmed cell death (apoptosis). This project will use acombination of yeast genetics, cell biology and biochemistry to understandhow these two critical cellular pathways are interrelated.

真核细胞必须协调大量的细胞过程才能正常工作。了解这是如何实现的对于生物科学的许多领域都是至关重要的。Vps45蛋白调节通过内体系统的膜交通，并在防止细胞进入程序性细胞死亡（凋亡）中发挥作用。该项目将结合酵母遗传学、细胞生物学和生物化学来了解这两个关键的细胞通路是如何相互关联的。