2003 Oxygen Radicals in Biology Gordon Conference

描述(申请人提供)：戈登“生物学中的氧自由基”研究会议旨在为环境毒理学家、生物学家、生物化学家、细胞生物学家、临床医生和其他生物医学科学家提供有关活性氧物种及其与其他自由基(包括一氧化氮)在对环境毒物的生物反应中的相互作用以及慢性病的病因学方面的最新知识。本次研究会议每两年举行一次；下一次会议将于2004年2月8日至13日在加利福尼亚州文图拉的文图拉海滩万豪酒店举行。自1981年以来，已举行了12次会议，根据大量申请者和会后评价，这些会议已证明非常富有成效。请拨资金部分用于支付来自美国的演讲者和富有成效的研究生/博士后候选人的旅费、生活费和注册费。本方案中列出的发言者是根据上届会议的前任主席、联合主席和与会者的建议选出的。演讲者被邀请介绍他们在生物学中对氧自由基的最新研究。将涵盖的主题包括：抗氧化剂的作用机制；蛋白质氧化的机制和后果；硫醇氧化还原状态和细胞功能的调节；环境暴露毒素背景下的氧化还原细胞信号；以及心血管和神经退行性疾病。此外，布鲁斯·弗里曼教授还将发表题为《从黄嘌呤氧化酶到一氧化氮：循环中的自由基》的全体讲座。预计将举行两次为期两天的海报发布活动，预计将发布50-70张海报。根据戈登会议的规定，总出席人数限制为135人。戈登会议为与会者和研究领域的多样性提供了一个极好的和亟需的论坛。本次戈登研究会议的主要优势是为不同学科的科学家提供了以延长和不间断的方式进行互动的机会。这种类型的互动通常会导致新的合作研究倡议。戈登生物氧自由基研究会议在探索这一重要领域的前沿研究方面发挥了至关重要的作用，这一领域与理解环境暴露和慢性疾病发生的分子事件有关。

Description (provided by applicant): The Gordon Research Conference on "Oxygen Radicals in Biology" is designed to provide environmental toxicologists, biologists, biochemists, cell biologists, clinicians, and other biomedical scientists with state of the art knowledge on reactive oxygen species and their interactions with other radicals, including nitric oxide, in the biological responses to environmental toxicants and the etiology of chronic diseases. This research conference is held every two years; the next meeting will be held February 8-13, 2004 at the Ventura Beach Marriot Hotel, Ventura, California. Twelve conferences have been held since 1981 and they have proven to be extremely productive based on the large number of applicants and the post-meeting evaluations. Funds are requested to partially support travel subsistence and registration costs for speakers from the United States and productive graduate students/post-doctoral candidates. The speakers listed in this program were selected based on the suggestions from the previous chairs, co-chairs and attendees at the past conference. Speakers have been invited to present their latest research on oxygen radicals in biology. Topics to be covered include: mechanisms of action of antioxidants; mechanism and consequences of protein oxidation; the regulation of thiol redox state and cellular function; the redox cell signaling in the context of environmental exposure to toxins; and cardiovascular and neurodegenerative diseases. In addition, Professor Bruce Freeman will present a Plenary Lecture entitled: "From Xanthine Oxidase to Nitric Oxide; Radicals in Circulation." Two separate poster sessions of two days each are scheduled for an anticipated 50-70 posters. Total attendance is limited to 135 by Gordon Conference rules. The Gordon Conference provides an excellent and much needed forum for the diversity of both participants and research areas. The main strength of this Gordon Research Conference is the opportunities offered for scientists in different disciplines to interact in an extended and uninterrupted fashion. This type of interaction generally results in new collaborative research initiatives. The Gordon Research Conference on Oxygen Radicals in Biology plays a crucial role in exploring frontier research in this important field relevant to understanding of the molecular events that occur on environmental exposure and chronic disease.