Immune Evasion

免疫逃避

• 批准号: 6747202
• 负责人: GIORGIO TRINCHIERI
• 金额: $ 0.8万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-02-01 至 2005-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6747202
• 关键词: host organism interaction; immune response; immunity; meeting /conference /symposium; travel

DESCRIPTION (provided by applicant): Infectious pathogens and tumors use many mechanisms to evade an immune response and survive in the organisms. Some of the same mechanisms are of relevance for the regulation of tolerance to self-antigens or its breakdown in autoimmunity. Their modulation may also result in successful graft take Infectious pathogens and tumors use many mechanisms to evade an immune response and survive in the organisms. Some of the same mechanisms are of relevance for the regulation of tolerance to self-antigens or its breakdown in autoimmunity. Their modulation may also result in successful graft take or rejection in organ transplantation. In the recent years there has been great progress in the understanding of many of these mechanisms that are very diverse but all result in the escape of the pathogen or tumor from an effective immune response with deleterious effect. Infectious disease immunity has been teaching us much about the mechanisms of immune evasion and what we have learned from these studies has greatly contributed to the understanding of cancer immune evasion and of the immunological mechanisms regulating autoimmunity and graft rejection. Because this meeting will be concurrent with a meeting on Microbial Latency (The Pathogen-Host Standoff: Persistent and Latent Infection), we have included only a limited number of presentations on immune evasion in infections (which is the major mechanism of microbial latency). The presentations on immunity to infections are limited to those fields (e.g. immunodeviation or oncogenic viruses) that provided important information for the understanding of the mechanisms of immune evasion. We have attempted to cover many aspects of immune evasion in cancer as well as to provide examples of the importance of similar mechanisms in autoimmunity, transplantation, and pregnancy.

描述（由申请人提供）：感染性病原体和肿瘤使用许多机制来逃避免疫应答并在生物体中存活。一些相同的机制与调节对自身抗原的耐受性或其在自身免疫中的破坏有关。它们的调节也可能导致成功的移植，感染性病原体和肿瘤使用许多机制来逃避免疫反应并在生物体中存活。一些相同的机制与调节对自身抗原的耐受性或其在自身免疫中的破坏有关。它们的调节也可能导致器官移植中的成功移植或排斥。近年来，在理解这些机制中的许多机制方面取得了很大进展，这些机制非常多样，但都导致病原体或肿瘤从有效的免疫应答中逃逸，产生有害影响。传染病免疫已经教会了我们很多关于免疫逃避机制的知识，我们从这些研究中所学到的知识极大地促进了对癌症免疫逃避以及调节自身免疫和移植物排斥的免疫机制的理解。由于本次会议将与微生物潜伏期会议（病原体-宿主稳定性：持续性和潜伏性感染）同时举行，因此我们只包括了有限数量的关于感染中免疫逃避的演讲（这是微生物潜伏期的主要机制）。关于感染免疫的介绍仅限于那些为理解免疫逃避机制提供重要信息的领域（例如免疫偏离或致癌病毒）。我们试图涵盖癌症中免疫逃避的许多方面，并提供类似机制在自身免疫、移植和妊娠中的重要性的例子。