Supporting Human ART Through Basic Science

通过基础科学支持人类艺术

• 批准号: 6706449
• 负责人: BARRY DOUGLAS BAVISTER
• 金额: $ 0.6万
• 依托单位: FEDERATED ANIMAL SCIENCE SOCIETIES
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-12-01 至 2004-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6706449
• 关键词: Chordata; assistive reproductive technique; biotechnology; embryo /fetus transplantation; fertility; in vitro fertilization; information dissemination; meeting /conference /symposium; science education; travel

DESCRIPTION (provided by applicant): This application seeks support for a 1-day symposium to be held in conjunction with the January 2004 Annual Meeting of the International Embryo Transfer Society in Portland, OR. The purpose of this symposium is twofold: (1) educate human Assisted Reproductive Technology (ART) practitioners (clinical embryologists and medical directors) in the latest basic and applied science relevant to their IVF programs, and (2) foster communication, exchange of information and awareness of how animal embryo research can address key problems in human IVF practice. These problems include: measurement of oocyte quality, selection of the most viable embryos for transfer and the etiology of defects in in vitro produced (IVP) embryos. At the same time, basic scientists will become aware of the practical problems inherent in human IVF clinics, by personal interactions with clinical personnel. These interactions will be strengthened by providing support for the speakers to attend the lnternational Embryo Transfer Society (IETS) meeting immediately following the symposium. Rationale: many aspects of human ART parallel those used in animal IVP. The first human in vitro fertilization successes were directly derived from studies with animals. However, with only a few notable exceptions, during the past two decades there has been little knowledge or technology transfer between these two applications. As a result, IVP in laboratory and domesticated animals has in some respects advanced far beyond that of human IVP, e.g., the high success rates of bovine offspring production from in vitro matured oocytes, development of specialized embryo culture media, and basic understanding of regulatory mechanisms and anomalies in animal IVP embryos. Better integration of these two communities will enhance the missions of both. The lETS is uniquely positioned to serve as the forum for ongoing exchange of information, ideas and technology between the animal and human ART efforts. Members of lETS work with a wide variety of species, including laboratory, domesticated and endangered animals and non-human primates, and employ a range of approaches including genetic, molecular, cellular and whole animal techniques to examine diverse basic and applied aspects of embryo production and quality. This Symposium will attract members of the human ART community and scientists working in animal ART, and will provide a basis for continued and expanded interactions between these two groups.

描述（由申请人提供）：本申请寻求支持将于2004年1月在俄勒冈州波特兰举行的国际胚胎移植学会年会期间举行的为期一天的研讨会。本次研讨会的目的是双重的：（1）教育人类辅助生殖技术（ART）从业者（临床胚胎学家和医学总监）在最新的基础和应用科学相关的IVF计划，和（2）促进沟通，信息交流和认识如何动物胚胎研究可以解决关键问题在人类IVF实践。这些问题包括：测量卵母细胞质量，选择最有活力的胚胎进行移植，以及体外生产（IVP）胚胎缺陷的病因学。与此同时，基础科学家将通过与临床人员的个人互动，意识到人类试管婴儿诊所固有的实际问题。这些互动将通过为演讲者提供支持来加强，以参加研讨会后立即举行的国际胚胎移植协会（IETS）会议。 依据：人ART的许多方面与动物IVP中使用的相似。第一个人类体外受精成功直接来自动物研究。然而，除了少数明显的例外，在过去二十年中，这两种应用之间几乎没有知识或技术转让。因此，实验室和驯养动物的IVP在某些方面已经远远超过了人类IVP，例如，从体外成熟卵母细胞生产牛后代的高成功率，专门的胚胎培养基的开发，以及对动物IVP胚胎中的调节机制和异常的基本理解。这两个群体更好地融合将加强双方的使命。该lETS是唯一的定位，作为一个论坛，不断交流信息，思想和技术之间的动物和人类的艺术努力。lETS的成员与各种物种合作，包括实验室，驯养和濒危动物以及非人类灵长类动物，并采用一系列方法，包括遗传，分子，细胞和整体动物技术，以检查胚胎生产和质量的各种基本和应用方面。本次研讨会将吸引人类ART社区的成员和从事动物ART工作的科学家，并将为这两个群体之间持续和扩大的互动提供基础。