Expanding the power of genetic analysis of complex traits in multiply phenotyped twin sibships

扩大多表型双胞胎同胞中复杂性状遗传分析的能力

• 批准号: nhmrc : 1049894
• 负责人: A/Pr Sarah Medland
• 金额: $ 36.11万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/expanding-power-genetic-twin-sibships/112122
• 关键词: Expanding; power; genetic; analysis; complex

Our aim is to identify genes influencing common diseases including melanoma, asthma and cardiovascular disease. We measure adolescent twins for moliness, skin, hair and eye colour and a variety of blood traits. We have already found new genes for mole count, eye colour, skin damage, and several different blood cell types. For each of these disease traits there are many more genes to be found and these will inform new treatments. We plan to genotype 600 new families (2000 individuals) to help achieve this.

我们的目标是识别影响黑色素瘤、哮喘和心血管疾病等常见疾病的基因。我们测量青春期双胞胎的皮肤，头发和眼睛的颜色以及各种血液特征。我们已经发现了与痣数量、眼睛颜色、皮肤损伤和几种不同血细胞类型有关的新基因。对于这些疾病特征中的每一个，都有更多的基因有待发现，这些基因将为新的治疗方法提供信息。我们计划对600个新家庭（2000个个体）进行基因分型，以帮助实现这一目标。