Neuroendocrine Factors in Adolescent Obesity

青少年肥胖的神经内分泌因素

• 批准号: 6994904
• 负责人: Patrika M Tsai
• 金额: $ 5.35万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6994904
• 关键词: adolescence (12-20); appetite; blood chemistry; body composition; clinical research; dietary constituent; epidemiology; female; ghrelin; hormone regulation /control mechanism; human subject; insulin sensitivity /resistance; magnetic resonance imaging; nutrition related tag; obesity; photon absorptiometry; postdoctoral investigator; somatotropin

DESCRIPTION (provided by applicant): Obesity is an epidemic that is striking people at younger ages than ever before. Obesity is associated with changes in the secretory patterns of several hormones including ghrelin, growth hormone (GH), and insulin, which have not been examined in the adolescent age group. Ghrelin, a primarily gastric hormone, increases appetite and is a GH secretagogue. This study will compare the alteration in secretion of ghrelin and GH in overweight and normal weight adolescent girls through frequent blood sampling and GH stimulation testing with growth hormone releasing hormone and arginine. The relationship between these hormones and insulin resistance, measured by 1H-nuclear magnetic resonance spectroscopy, and body composition, measured by dual energy x-ray absorptiometry and magnetic resonance imaging, will be investigated. This study will also determine the postprandial ghrelin response to test meals that vary by the type of predominant macronutrient, which may predict the degree of hunger and amount of intake at a subsequent meal. Understanding obesity-related changes in ghrelin and GH and their relationship to body composition, insulin resistance, and appetite will help in the development of strategies to reduce complications of obesity.

描述（由申请人提供）：肥胖是一种流行病，其发病年龄比以往任何时候都更年轻。肥胖与多种激素分泌模式的变化有关，包括生长素释放肽、生长激素 (GH) 和胰岛素，但尚未在青少年年龄组中进行研究。生长素释放肽（Ghrelin）是一种主要的胃激素，可增加食欲，并且是 GH 促分泌素。本研究将通过频繁的血液采样和使用生长激素释放激素和精氨酸进行 GH 刺激测试，比较超重和正常体重青春期女孩的 ghrelin 和 GH 分泌变化。将研究这些激素与胰岛素抵抗（通过 1H 核磁共振波谱测量）和身体成分（通过双能 X 射线吸收测定法和磁共振成像测量）之间的关系。这项研究还将确定餐后生长素释放肽对测试膳食的反应，该反应因主要大量营养素的类型而异，这可以预测饥饿程度和后续膳食的摄入量。了解与肥胖相关的生长素释放肽和生长激素的变化及其与身体成分、胰岛素抵抗和食欲的关系将有助于制定减少肥胖并发症的策略。