Gifts that keep on giving: maternal effects and insect pest control

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Successful early embryonic development occurs as a result of a precise balance between the effects of both embryonic and maternal genomes. Very little of this process is known in key insect pests and it is of particular importance for effectively tackling serious agricultural pests such as the medfly (Ceratitis captita). This is an extreme generalist whose larvae can thrive in over 350 different host fruits, many of which are of global economic importance. Understanding the mechanisms and balance of maternal vs embryonic effects on development in this species is crucially important to reveal fundamental characteristics of generalist insect pests and to deliver new tools for population suppression.The project is a collaboration with the Pirbright Institute, a world-leading research centre for the development of genetic technologies. The project aims to identify and manipulate RNAs deposited in eggs by mothers in the medfly. This will reveal the fundamental role of these RNAs in the unusually wide dietary success of this species and offer significant potential to increase the efficiency of next generation genes drives through improvements to gene editing.