Inorganic approaches to 18F-based positron emission tomography (PET) imaging applications

基于 18F 的正电子发射断层扫描 (PET) 成像应用的无机方法

• 批准号: 2445849
• 金额: --
• 依托单位: University of Southampton
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2445849
• 关键词: Inorganic; approaches; 18F; based; positron

This is an experimentally based PhD studentship focused on the synthesis and radiofluorination of molecular inorganic complexes, typically involving d- or p-block Lewis acids with high fluoride affinity, bound to functionalised macrocyclic ligands for potential applications in medical imaging via Positron Emission Tomography (PET). The studentship is associated with a collaborative EPSRC Programme Grant, 'Next generation molecular imaging and therapy with radionuclides' led by King's College London, in collaboration with Imperial College London and the University of Southampton, while training and experience in radiolabelling experiments will take place in the School of Biomedical Engineering and Imaging Sciences at KCL (based at St Thomas' Hospital). The research is highly interdisciplinary, as well as developing strong skills in inorganic and macrocyclic coordination chemistry.

这是一个实验为基础的博士研究生，专注于分子无机复合物的合成和放射性，通常涉及具有高氟亲和力的d-或p-嵌段刘易斯酸，与功能化大环配体结合，通过正电子发射断层扫描（PET）在医学成像中的潜在应用。该奖学金与EPSRC合作项目资助有关，即由伦敦国王学院牵头，与伦敦帝国理工学院和南安普顿大学合作的“下一代放射性核素分子成像和治疗”，而放射性标记实验的培训和经验将在KCL的生物医学工程和成像科学学院（位于圣托马斯医院）进行。该研究是高度跨学科的，以及在无机和大环配位化学发展强大的技能。