Inorganic approaches to 18F-based positron emission tomography (PET) imaging applications

这是一个以实验为基础的博士研究生，专注于分子无机络合物的合成和放射性氟化，通常包括具有高氟亲和力的d-或p-嵌段Lewis酸，结合到功能化大环配体上，通过正电子发射断层扫描(PET)在医学成像中的潜在应用。该项目是由伦敦国王学院与伦敦帝国理工学院和南安普顿大学合作开展的一项名为“下一代放射性核素分子成像和治疗”的EPSRC项目资助项目，而放射性标记实验的培训和经验将在KCL生物医学工程和成像科学学院(总部设在圣托马斯医院)进行。这项研究是高度跨学科的，并在无机和大环配位化学方面发展了很强的技能。

This is an experimentally based PhD studentship focused on the synthesis and radiofluorination of molecular inorganic complexes, typically involving d- or p-block Lewis acids with high fluoride affinity, bound to functionalised macrocyclic ligands for potential applications in medical imaging via Positron Emission Tomography (PET). The studentship is associated with a collaborative EPSRC Programme Grant, 'Next generation molecular imaging and therapy with radionuclides' led by King's College London, in collaboration with Imperial College London and the University of Southampton, while training and experience in radiolabelling experiments will take place in the School of Biomedical Engineering and Imaging Sciences at KCL (based at St Thomas' Hospital). The research is highly interdisciplinary, as well as developing strong skills in inorganic and macrocyclic coordination chemistry.