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Investigating the interaction between plant cell wall integrity maintenance and innate immunity

研究植物细胞壁完整性维持与先天免疫之间的相互作用

基本信息

批准号：
2445934
负责人：
金额：
--
依托单位：
University of Oxford
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2020
资助国家：
英国
起止时间：
2020 至无数据
项目状态：
未结题

来源：
https://gtr.ukri.org/projects?ref=studentship-2445934
关键词：
Investigating interaction between plant cell

项目摘要

The plant cell wall provides structural support to individual cells in addition to acting as a physical barrier between the cell and the environment. Therefore, the cell wall serves as an important barrier to plant pathogens. In order to establish an infection, pathogens must bypass the cell wall to exert their influence on the host and to access its nutrients. Plants have evolved a complex innate immune system which enables the detection of conserved pathogen features, or the damage-associated products of their activity, which activate defence responses. Plant cells also possess a cell wall integrity (CWI) maintenance mechanism whereby receptors monitor the mechanical properties of the cell wall and trigger compensatory responses following cell wall damage. These two systems have been found to interact which influences plant defence responses. However, the molecular components that mediate this interaction are not well characterised. Furthermore, the effect of biotic stress on the mechanical properties of the cell wall and its consequences for the outcome of an infection remain poorly understood. Therefore, this project aims to characterise how the mechanical properties of the cell wall change during innate immunity. Additionally, the molecular components which mediate the interaction between CWI maintenance and innate immunity will be investigated. Understanding novel biotic stress tolerance mechanisms will help direct future strategies to improve the disease resistance of important crop species, helping to ensure food security in the 21st century.

植物细胞壁除了充当细胞与环境之间的物理屏障外，还为单个细胞提供结构支撑。因此，细胞壁是植物病原体的重要屏障。为了建立感染，病原体必须绕过细胞壁对宿主施加影响并获得其营养。植物已经进化出一种复杂的先天免疫系统，该系统能够检测保守的病原体特征或其活性的损伤相关产物，从而激活防御反应。植物细胞还具有细胞壁完整性（CWI）维持机制，由此受体监测细胞壁的机械性质并在细胞壁损伤后触发补偿反应。已经发现这两个系统相互作用，影响植物防御反应。然而，介导这种相互作用的分子组分没有得到很好的表征。此外，生物应力对细胞壁的机械性质的影响及其对感染结果的后果仍然知之甚少。因此，本项目旨在研究细胞壁的机械特性在先天免疫过程中如何变化。此外，介导CWI维持和先天免疫之间的相互作用的分子组分将被研究。了解新的生物胁迫耐受机制将有助于指导未来的战略，以提高重要作物品种的抗病性，有助于确保世纪的粮食安全。