Exploiting and defining the immune regulatory activities of BET bromodomain inhibitors

基于免疫的药物，如“检查点抑制剂”，有能力重新唤醒我们自己的免疫系统，并激活之前处于休眠状态的抗肿瘤反应。我们已经发现，在小鼠癌症模型中，被称为溴域蛋白的基因调控蛋白的小分子抑制剂与检查点抑制剂具有协同作用。我们将定义支持这一新的联合治疗方法的分子和生物学事件，并评估联合治疗在不同肿瘤中的效果。

Immune-based agents such as “checkpoint inhibitors” have the ability to re-awaken our own immune systems and activate previously dormant anti-tumor responses. We have discovered that small molecule inhibitors of gene regulatory proteins called bromodomain proteins act synergistically with checkpoint inhibitors in mouse cancer models. We will define the molecular and biological events underpinning this novel combination approach and assess the effects of the combination across different tumors.