Applied Preventive Cardiology Research

应用预防心脏病学研究

• 批准号: 6918168
• 负责人: LORI J MOSCA
• 金额: $ 14.99万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6918168
• 关键词: antihypercholesterolemic agent; behavioral /social science research tag; blood tests; cardiovascular disorder education; cardiovascular disorder prevention; cardiovascular disorder risk; cholesterol; clinical research; clinical trials; cost effectiveness; family; gender difference; human subject; human therapy evaluation; lifestyle; low density lipoprotein; outcomes research; patient oriented research; physicians; primary care physician; racial /ethnic difference; therapy compliance

DESCRIPTION (provided by applicant): Despite extensive research documenting the efficacy of cardiovascular disease (CVD) preventive strategies, these are not uniformly applied across diverse patient populations. The applicant for this Midcareer Investigator Award, Dr. Lori Mosca, has an outstanding record of commitment to patient-oriented research to evaluate gender and ethnic differences in CVD risk, barriers to preventive care, and novel methods to increase patient adherence to national prevention guidelines. She has held an NHLBI National Research Career Award in Preventive Cardiology and an NHLBI Mentored Clinical Scientist Development Grant. The K24 grant will support Dr. Mosca to continue a scientific trajectory directed to mentor the next generation of applied scientists in preventive cardiology and to further refine her research skills related to evaluating interventions to improve lifestyle and outcomes in diverse patients at risk for CVD events. The long-term goal of this project is to increase the number and quality of clinical scientists dedicated to research to improving the quality of CVD preventive care in diverse populations. The specific aims are to 1) Protect Dr. Mosca's time to mentor and conduct patient-oriented research in CVD prevention while advancing her skills in clinical research focused on quality CVD outcomes through formal courses, 2) Establish a structured mentoring program in patient-oriented CVD prevention research targeted to early career investigators, and 3) Support new research to test the impact of an intervention involving Dr, Mosca to increase adherence to national guidelines for CVD prevention among 370 high risk patients. A proposed clinical trial takes advantage of the infrastructure of an ongoing study to identify family members and visitors of patients hospitalized with CVD that may also be at increased risk of CVD events due to shared genes and/or lifestyle. The primary outcome of the trial is the % of high risk patients that achieve an optimal cholesterol level at 1 year compared to those receiving a control intervention. Other ongoing studies funded by the NIH and foundations will provide an enriched research environment to support the K24 goals. Columbia University is uniquely suited to train clinical scientists in issues related to minority and women's cardiovascular health as many of our studies have nearly 50% participation by these populations. The research and careers supported by this project are expected to have a positive impact on attainment of the Healthy People 2010 lifestyle and CVD prevention.

描述（由申请人提供）： 尽管广泛的研究记录了心血管疾病（CVD）预防策略的有效性，但这些策略并没有统一应用于不同的患者人群。洛里莫斯卡博士是这项中期研究奖的申请人，他致力于以患者为导向的研究，以评估CVD风险的性别和种族差异，预防护理的障碍，以及增加患者遵守国家预防指南的新方法。她曾获得NHLBI预防心脏病学国家研究职业奖和NHLBI指导临床科学家发展补助金。K24赠款将支持莫斯卡博士继续指导下一代预防心脏病学应用科学家的科学轨迹，并进一步完善她与评估干预措施有关的研究技能，以改善各种有CVD事件风险的患者的生活方式和结局。该项目的长期目标是增加致力于研究的临床科学家的数量和质量，以提高不同人群中CVD预防护理的质量。具体目标是：1）保护莫斯卡博士指导和开展以患者为导向的心血管疾病预防研究的时间，同时通过正式课程提高她在临床研究中的技能，重点关注高质量的心血管疾病结局，2）针对早期职业研究人员建立以患者为导向的心血管疾病预防研究的结构化指导计划，3）支持新的研究，以测试涉及莫斯卡博士的干预措施的影响，莫斯卡在370名高危患者中增加对国家CVD预防指南的依从性。一项拟议的临床试验利用正在进行的研究的基础设施，以确定因共同基因和/或生活方式而可能增加CVD事件风险的CVD住院患者的家庭成员和访客。试验的主要结局是与接受对照干预的患者相比，在1年时达到最佳胆固醇水平的高风险患者的百分比。由NIH和基金会资助的其他正在进行的研究将提供一个丰富的研究环境，以支持K24目标。哥伦比亚大学是唯一适合培训临床科学家在有关少数民族和妇女的心血管健康的问题，因为我们的许多研究有近50%的参与这些人群。该项目支持的研究和职业有望对实现2010年健康人生活方式和预防心血管疾病产生积极影响。