Applied Preventive Cardiology Research

应用预防心脏病学研究

• 批准号: 7619027
• 负责人: LORI J MOSCA
• 金额: $ 14.99万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2010-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7619027
• 关键词: Adherence; Award; Cardiology; Cardiovascular Diseases; Cardiovascular system; Caring; Cholesterol; Clinical; Clinical Research; Clinical Trials; Control Groups; Development; Disease Outcome; Education; Effectiveness; Environment; Ethnic Origin; Event; Family member; Foundations; Funding; Gender; Genes; Goals; Grant; Guidelines; Health; Healthy People 2010; Intervention; Life Style; Low-Density Lipoproteins; Mentors; Methods; Minority; National Heart, Lung, and Blood Institute; Outcome; Patients; Physicians; Population; Population Heterogeneity; Prevention; Prevention Guidelines; Prevention Research; Prevention strategy; Preventive; Research; Research Infrastructure; Research Personnel; Resources; Scientist; Secondary Prevention; Structure; Testing; Time; Training; United States National Institutes of Health; Universities; Woman; base; cardiovascular disorder prevention; cardiovascular disorder risk; career; compliance behavior; cost effectiveness; ethnic difference; high risk; improved; loris; next generation; novel; patient oriented; patient oriented research; patient population; primary outcome; programs; sex; skills; treatment as usual

DESCRIPTION (provided by applicant): Despite extensive research documenting the efficacy of cardiovascular disease (CVD) preventive strategies, these are not uniformly applied across diverse patient populations. The applicant for this Midcareer Investigator Award, Dr. Lori Mosca, has an outstanding record of commitment to patient-oriented research to evaluate gender and ethnic differences in CVD risk, barriers to preventive care, and novel methods to increase patient adherence to national prevention guidelines. She has held an NHLBI National Research Career Award in Preventive Cardiology and an NHLBI Mentored Clinical Scientist Development Grant. The K24 grant will support Dr. Mosca to continue a scientific trajectory directed to mentor the next generation of applied scientists in preventive cardiology and to further refine her research skills related to evaluating interventions to improve lifestyle and outcomes in diverse patients at risk for CVD events. The long-term goal of this project is to increase the number and quality of clinical scientists dedicated to research to improving the quality of CVD preventive care in diverse populations. The specific aims are to 1) Protect Dr. Mosca's time to mentor and conduct patient-oriented research in CVD prevention while advancing her skills in clinical research focused on quality CVD outcomes through formal courses, 2) Establish a structured mentoring program in patient-oriented CVD prevention research targeted to early career investigators, and 3) Support new research to test the impact of an intervention involving Dr, Mosca to increase adherence to national guidelines for CVD prevention among 370 high risk patients. A proposed clinical trial takes advantage of the infrastructure of an ongoing study to identify family members and visitors of patients hospitalized with CVD that may also be at increased risk of CVD events due to shared genes and/or lifestyle. The primary outcome of the trial is the % of high risk patients that achieve an optimal cholesterol level at 1 year compared to those receiving a control intervention. Other ongoing studies funded by the NIH and foundations will provide an enriched research environment to support the K24 goals. Columbia University is uniquely suited to train clinical scientists in issues related to minority and women's cardiovascular health as many of our studies have nearly 50% participation by these populations. The research and careers supported by this project are expected to have a positive impact on attainment of the Healthy People 2010 lifestyle and CVD prevention.

描述（由申请人提供）： 尽管大量研究证明了心血管疾病 (CVD) 预防策略的有效性，但这些策略并未统一应用于不同的患者群体。该职业生涯中期研究员奖的申请人 Lori Mosca 博士在致力于以患者为导向的研究方面有着杰出的记录，这些研究旨在评估 CVD 风险的性别和种族差异、预防性护理的障碍以及提高患者遵守国家预防指南的新方法。她曾获得 NHLBI 预防心脏病学国家研究职业奖和 NHLBI 指导临床科学家发展补助金。 K24 拨款将支持 Mosca 博士继续走科学之路，指导下一代预防心脏病学应用科学家，并进一步完善她与评估干预措施相关的研究技能，以改善面临 CVD 事件风险的不同患者的生活方式和结果。该项目的长期目标是增加致力于研究的临床科学家的数量和质量，以提高不同人群的 CVD 预防护理质量。具体目标是 1) 保护 Mosca 博士在 CVD 预防方面指导和开展以患者为导向的研究的时间，同时通过正式课程提高她在专注于优质 CVD 结果的临床研究方面的技能，2) 建立针对早期职业研究人员的以患者为导向的 CVD 预防研究的结构化指导计划，以及 3) 支持新的研究，以测试 Mosca 博士参与的干预措施的影响，以提高对国家指南的遵守率 370名高危患者的CVD预防。拟议的临床试验利用正在进行的研究的基础设施来识别因 CVD 住院的患者的家庭成员和访客，这些患者也可能由于共享基因和/或生活方式而面临 CVD 事件风险增加的风险。该试验的主要结果是与接受对照干预的患者相比，一年后达到最佳胆固醇水平的高风险患者的百分比。由 NIH 和基金会资助的其他正在进行的研究将为支持 K24 目标提供丰富的研究环境。哥伦比亚大学非常适合培训少数族裔和女性心血管健康相关问题的临床科学家，因为我们的许多研究都有近 50% 的这些人群参与。该项目支持的研究和职业预计将对实现“健康人2010”生活方式和心血管疾病预防产生积极影响。