Growth and Physical Maturation in Cerebral Palsy

脑瘫的生长和身体成熟

• 批准号: 6932106
• 负责人: RICHARD D STEVENSON
• 金额: $ 10.34万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-08 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6932106
• 关键词: behavioral /social science research tag; bone density; cerebral palsy; child physical development; child with disability; children; clinical research; clinical trials; cyproheptadine; developmental nutrition; diphosphonate; functional ability; human puberty; human subject; human therapy evaluation; longitudinal human study; malnutrition; metabolism disorder chemotherapy; nutrition related tag; osteopenia; patient oriented research; quality of life; vitamin therapy

DESCRIPTION (provided by applicant): This Mid-Career Award is requested to support the continued research development and mentoring activities of Richard D. Stevenson, MD, Associate Professor of Pediatrics at the University of Virginia (UVA). Over the past 10 years, Dr. Stevenson has shown a commitment to patient-oriented research and mentoring of new investigators. He is the principal investigator of a focused research effort investigating the importance of growth, nutrition, and physical development on the health and quality of life of children with cerebral palsy (CP). The goals of this proposal for research training, mentoring, and clinical research (respectively) are to (1) transition the applicant's research program of descriptive studies that have identified problems and trends to clinical trials that will test hypotheses toward the improvement of child health, (2) provide training and mentorship in clinical research (in general) and clinical research in persons with disabilities (specifically), and (3) maximize the health, participation and quality of life of children with CP and their families through the management of growth, nutritional status and other secondary conditions. The applicant is requesting K-24 funding to devote 50% of his time toward these pursuits. The next 5 years are critical to the consolidation of the applicant's research program and the expansion of his efforts through the mentoring and training of new investigators. The research training plan has been significantly expanded with this revision in response to the last review. It includes coursework, study, and practice in the development and conduct of clinical trials in persons with disabilities. This training will be accomplished through enrollment in the Multidisciplinary Training Program in Clinical Investigation, formal coursework through UVA's Department of Health Evaluation Sciences, and through collaborative efforts with colleagues. The mentoring plan has been simplified and includes (1) development of a patient-oriented research curriculum for residents, fellows, and faculty in pediatrics, developmental medicine and rehabilitation, using all resources available at UVA, (2) focused mentoring of the new investigators with the development of individualized research plans with each mentee, and (3) mentored completion of discrete research projects by each mentee. The research plan consists of studies that are part of the North American Growth in Cerebral Palsy Project (NAGCPP), and focuses on the development of clinical trials of nutritional interventions for the treatment and prevention of malnutrition. As poor growth and malnutrition are common, and as children with CP can be considered a clinical model of individuals with disabilities at large, this work is important and highly relevant to populations of children and adults with developmental and acquired disabilities.

描述(由申请人提供)：此职业中期奖旨在支持弗吉尼亚大学(UVA)儿科学副教授理查德·D·史蒂文森医学博士的持续研究发展和指导活动。在过去的10年里，史蒂文森博士一直致力于以患者为导向的研究，并指导新的研究人员。他是一项重点研究工作的首席研究员，该研究旨在调查生长、营养和身体发育对脑瘫(CP)儿童健康和生活质量的重要性。这项研究培训、指导和临床研究的建议的目标分别是(1)将申请人的描述性研究计划转变为临床试验，以检验改善儿童健康的假设，(2)提供临床研究(一般)和残疾人临床研究(具体)方面的培训和指导，以及(3)通过对生长发育、营养状况和其他次要条件的管理，最大限度地提高CP儿童及其家人的健康、参与度和生活质量。申请者正在申请K-24资助，以便将他50%的时间用于这些追求。未来5年是申请人巩固研究计划和通过指导和培训新的研究人员扩大其努力的关键时期。针对上一次审查，这次修订大大扩展了研究培训计划。它包括开发和实施残疾人临床试验的课程、研究和实践。这项培训将通过注册临床研究多学科培训计划、通过弗吉尼亚大学健康评估科学部的正式课程以及通过与同事的合作来完成。指导计划已得到简化，包括(1)利用弗吉尼亚大学的所有资源，为儿科、发展医学和康复方面的住院医生、研究员和教职员工制定以患者为中心的研究课程，(2)重点指导新的研究人员，与每个指导对象一起制定个性化的研究计划，以及(3)由每个指导对象指导完成不同的研究项目。该研究计划包括北美脑瘫生长项目(NAGCPP)的一部分，重点是开发治疗和预防营养不良的营养干预的临床试验。由于发育不良和营养不良很常见，而且患有脑瘫的儿童可以被视为一般残疾个人的临床模型，这项工作对患有发展性和获得性残疾的儿童和成人群体非常重要和高度相关。