NORTH AMERICAN GROWTH IN CEREBRAL PALSY PROJECT

北美脑瘫项目的增长

• 批准号: 6183002
• 负责人: RICHARD D STEVENSON
• 金额: $ 10.98万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-27 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6183002
• 关键词: North America; adolescence (12-20); behavioral /social science research tag; body height; body physical characteristic; cerebral palsy; child (0-11); child physical development; clinical research; data collection methodology /evaluation; developmental nutrition; functional ability; human data; human population study; human puberty; human subject; immunity; medical rehabilitation related tag; nervous system disorder epidemiology; neuroendocrine system; nutrition related tag; outcomes research; quality of life; somatotropin; statistics /biometry

Normal growth in children is generally accepted as a marker for health, while abnormal growth is a marker that the child may be ill or malnourished or that something may be awry in the child's environment. Children with cerebral palsy (CP) frequently grow poorly. However, normal growth patterns for children with CP have not been established, so it is often difficult to discriminate children with CP who are healthy from those who are ill. The North American Growth in Cerebral Palsy Project (NAGCePP) was developed to address the lack of data regarding growth and nutritional status in children with Cerebral Palsy. The specific aims of this proposal are: A. To refine a clinical protocol and methodology for the comprehensive study of growth and nutritional status in children with CP B. To develop a well-equipped, multicenter network for the comprehensive study of growth and nutritional status in children with CP and to demonstrate the feasibility of this network C. To collect pilot data of growth in a representative, population- based sample of children with CP in five geographic areas in North America D. To complete collection of data of a representative, population- based sample of children with CP in order to describe expected growth patterns NAGCePP will consist of a multicenter core study coupled with one or more nested studies. The core study is to be anthropometric study of growth in a population-based, random sample of children with CP to which all centers will contribute data. Additionally, individual centers will have ongoing nested studies utilizing small subsamples to which only that individually site (or a few sites) contributes data. These nested studies will address more specific questions related to growth, nutritional status, and their effects on functional status and quality of life. This proposal requests funds for the multicenter core study and for the first nested study, which will be performed at the main study and for the first nested study, which will be performed at the main study site. This proposal aims to contribute information toward the understanding of normal growth and nutritional status in children with cerebral palsy. An understanding of normal growth in these children is a prerequisite to understanding the relationship between growth, nutritional status, functional abilities and health-related quality of life

儿童的正常生长通常被认为是 健康，而不正常的增长是一个标志，儿童可能生病或 营养不良或孩子的身体可能出了问题， 环境 小儿脑瘫（脑瘫）的治疗方法 很糟糕 然而，CP儿童的正常生长模式 没有建立，所以往往很难歧视儿童， 健康的人和生病的人。 北美 脑性瘫痪项目（NAGCePP）的发展， 解决缺乏生长和营养状况数据的问题 小儿脑瘫的治疗方法 这项建议的具体目标是： A. 完善临床方案和方法， 儿童生长和营养状况的综合研究 CP B。 建立一个设备完善的多中心网络， 儿童生长和营养状况的综合研究 CP，并论证该网络的可行性 C. 收集具有代表性的人口增长的试验数据- 在北部五个地理区域的CP儿童样本 美国 D. 为了完成具有代表性的人口数据的收集- 为描述预期的生长， 模式 NAGCePP将包括一项多中心核心研究， 更多的嵌套研究。 核心研究是人体测量研究， 在以人群为基础的随机抽样的CP儿童中， 所有中心都将提供数据。 此外，个别中心 将利用小子样进行嵌套研究， 只有个别站点（或几个站点）提供数据。 这些 嵌套研究将解决与增长有关的更具体的问题， 营养状况，以及它们对功能状况和质量的影响 生活 该提案要求为多中心核心研究提供资金， 对于第一项嵌套研究，将在主研究中进行 对于第一项嵌套研究，将在主研究中心进行 研究中心。 该提案旨在为以下方面提供信息： 了解儿童的正常生长和营养状况， 脑瘫 了解这些孩子的正常成长 是理解经济增长和人口增长之间关系的前提， 营养状况、功能能力和健康相关生活质量