NORTH AMERICAN GROWTH IN CEREBRAL PALSY PROJECT

儿童的正常生长被普遍认为是一个标志 健康，而异常生长则表明孩子可能生病或 营养不良或孩子的身体可能出现问题 环境。 脑瘫 (CP) 儿童经常生长 很差。 然而，脑瘫儿童的正常生长模式 尚未建立，因此通常很难歧视儿童 CP 分为健康者和患病者。 北美 脑瘫成长项目 (NAGCePP) 的开发目的是 解决缺乏有关生长和营养状况数据的问题 脑瘫儿童。 该提案的具体目标是： A. 完善临床方案和方法 儿童生长发育和营养状况的综合研究 CP B. 建立一个装备精良的多中心网络 儿童生长发育和营养状况的综合研究 CP并证明该网络的可行性 C. 收集代表性人口增长的试点数据 北部五个地理区域的脑瘫儿童样本 美国 D. 完成代表性人口数据的收集- 基于患有 CP 的儿童样本，以描述预期的生长 图案 NAGCePP 将包括一项多中心核心研究以及一项或多项研究 更多嵌套研究。 核心研究是人体测量研究 基于人口的 CP 儿童随机样本的增长 所有中心都将提供数据。 此外，个别中心 将利用小子样本进行持续的嵌套研究 只有单个站点（或几个站点）提供数据。 这些 嵌套研究将解决与增长相关的更具体的问题， 营养状况及其对功能状态和品质的影响 生活。 该提案要求为多中心核心研究提供资金 对于第一个嵌套研究，将在主要研究中进行 对于第一个嵌套研究，该研究将在主要执行 学习网站。 该提案旨在为以下方面提供信息： 了解患有此病的儿童的正常生长和营养状况 脑瘫。 了解这些儿童的正常生长 是理解增长之间关系的先决条件， 营养状况、功能能力和健康相关的生活质量

Normal growth in children is generally accepted as a marker for health, while abnormal growth is a marker that the child may be ill or malnourished or that something may be awry in the child's environment. Children with cerebral palsy (CP) frequently grow poorly. However, normal growth patterns for children with CP have not been established, so it is often difficult to discriminate children with CP who are healthy from those who are ill. The North American Growth in Cerebral Palsy Project (NAGCePP) was developed to address the lack of data regarding growth and nutritional status in children with Cerebral Palsy. The specific aims of this proposal are: A. To refine a clinical protocol and methodology for the comprehensive study of growth and nutritional status in children with CP B. To develop a well-equipped, multicenter network for the comprehensive study of growth and nutritional status in children with CP and to demonstrate the feasibility of this network C. To collect pilot data of growth in a representative, population- based sample of children with CP in five geographic areas in North America D. To complete collection of data of a representative, population- based sample of children with CP in order to describe expected growth patterns NAGCePP will consist of a multicenter core study coupled with one or more nested studies. The core study is to be anthropometric study of growth in a population-based, random sample of children with CP to which all centers will contribute data. Additionally, individual centers will have ongoing nested studies utilizing small subsamples to which only that individually site (or a few sites) contributes data. These nested studies will address more specific questions related to growth, nutritional status, and their effects on functional status and quality of life. This proposal requests funds for the multicenter core study and for the first nested study, which will be performed at the main study and for the first nested study, which will be performed at the main study site. This proposal aims to contribute information toward the understanding of normal growth and nutritional status in children with cerebral palsy. An understanding of normal growth in these children is a prerequisite to understanding the relationship between growth, nutritional status, functional abilities and health-related quality of life