NORTH AMERICAN GROWTH IN CEREBRAL PALSY PROJECT

儿童的正常发育通常被认为是 健康，而异常生长是孩子可能生病或 营养不良，或者孩子的身体可能有问题 环境。脑性瘫痪(CP)儿童经常发育 很差。然而，患有CP的儿童的正常生长模式有 没有被确立，因此往往很难歧视儿童 与那些健康的CP从那些生病的人。北美人 脑瘫成长项目(NAGCePP)被开发为 解决缺乏有关生长和营养状况的数据的问题 脑性瘫痪的儿童。这项建议的具体目标是： A.完善临床方案和方法学 儿童生长发育与营养状况的综合研究 CP B.发展一个设备完善的多中心网络，为 儿童生长发育与营养状况的综合研究 CP，并论证该网络的可行性 C.收集具有代表性的人口增长的试点数据- 北方五个地理区域儿童脑瘫的抽样调查 美国 D.完成代表性人口数据的收集-- 基于脑瘫儿童样本，以描述预期生长发育 图案 NAGCePP将由一项多中心核心研究与一项或 更多嵌套研究。核心研究是人体测量研究 以人群为基础的CP儿童随机样本的生长发育 所有中心都将提供这些数据。此外，个别中心 将利用较小的子样本进行持续的嵌套研究 只有那个单独的站点(或几个站点)提供数据。这些 嵌套研究将解决与增长相关的更具体的问题， 营养状况及其对功能状况和质量的影响 生活。该提案要求为多中心核心研究提供资金，并 对于将在主研究中执行的第一个嵌套研究 对于第一个嵌套研究，将在主要 学习地点。这项提案旨在为 对儿童正常生长发育和营养状况的了解 脑性瘫痪。对这些儿童正常生长发育的理解 是理解增长和发展之间关系的先决条件 营养状况、功能能力与健康相关生活质量

Normal growth in children is generally accepted as a marker for health, while abnormal growth is a marker that the child may be ill or malnourished or that something may be awry in the child's environment. Children with cerebral palsy (CP) frequently grow poorly. However, normal growth patterns for children with CP have not been established, so it is often difficult to discriminate children with CP who are healthy from those who are ill. The North American Growth in Cerebral Palsy Project (NAGCePP) was developed to address the lack of data regarding growth and nutritional status in children with Cerebral Palsy. The specific aims of this proposal are: A. To refine a clinical protocol and methodology for the comprehensive study of growth and nutritional status in children with CP B. To develop a well-equipped, multicenter network for the comprehensive study of growth and nutritional status in children with CP and to demonstrate the feasibility of this network C. To collect pilot data of growth in a representative, population- based sample of children with CP in five geographic areas in North America D. To complete collection of data of a representative, population- based sample of children with CP in order to describe expected growth patterns NAGCePP will consist of a multicenter core study coupled with one or more nested studies. The core study is to be anthropometric study of growth in a population-based, random sample of children with CP to which all centers will contribute data. Additionally, individual centers will have ongoing nested studies utilizing small subsamples to which only that individually site (or a few sites) contributes data. These nested studies will address more specific questions related to growth, nutritional status, and their effects on functional status and quality of life. This proposal requests funds for the multicenter core study and for the first nested study, which will be performed at the main study and for the first nested study, which will be performed at the main study site. This proposal aims to contribute information toward the understanding of normal growth and nutritional status in children with cerebral palsy. An understanding of normal growth in these children is a prerequisite to understanding the relationship between growth, nutritional status, functional abilities and health-related quality of life