Medicinal products in the environment: novel strategies reducing environmental exposure

环境中的医药产品：减少环境暴露的新策略

• 批准号: 2446460
• 金额: --
• 依托单位: University of Bath
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2446460
• 关键词: Medicinal; products; environment; novel; strategies

There is an urgent need to reduce pharmaceutical levels in the environment due their impact on natural environmentand humans, as well as to comply with changing water quality regulations. Pharmaceuticals in the environment aremainly attributed to the discharge of treated effluent from wastewater treatment works. The water sector is thereforekeen to advance knowledge in this area. The water sector and regulators have prioritised pharmaceutical compoundsfor further investigation, which are prescribed in relation to conditions such as cardiovascular disease, obesity,diabetes and depression/anxiety. Some of the conditions are related to lifestyle choices.To reduce the load of pharmaceuticals in the environment, greater control and treatment at wastewater treatmentworks could be needed. However, this would lead to a significant increase in the costs of wastewater treatment,embedded and operational carbon in addition to an increase in water bills. This is in addition to the wider costs ofillness to society, which pays twice to exacerbate a problem. The current situation is therefore unsustainable andneeds disruptive change. The intention of this project is to provide the data and evidence to help prompt thatchange.This project will focus on the development of water fingerprinting approaches with utilisation of powerful massspectrometry techniques: triple quadrupole analysis for selected pharmaceutical targets and high-resolution massspectrometry for non-target/retrospective analysis of environmental and public health determinants.Water fingerprinting has the potential to revolutionise health-care provision as it can provide real-time and costeffectivecommunity-wide public health diagnostics, since urban water can be considered as a diagnostic medium forthe health status of a community and surrounding environment.The project will:1. Develop mass spectrometry focussed frameworks for spatiotemporal water fingerprinting2. Undertake analysis of longitud inal samples collected in the Somer Valley (wastewater and receiving environment)to establish spatiotemporal trends in environmental and public health determinants (pharmaceuticals, metabolites,endogenously formed markers).3. Undertake data triangulation to verify environmental and public health status and risk assessmentIn order to develop and apply an approach as a measure of public health status in the studied region and tool forevaluating the effectiveness of interventions.

由于药物对自然环境和人类的影响，迫切需要降低环境中的药物水平，并遵守不断变化的水质法规。环境中的药物主要是由于废水处理厂排放的经过处理的废水。因此，水务部门热衷于推进这一领域的知识。水部门和监管机构已优先考虑进一步调查的药物化合物，这些化合物是与心血管疾病、肥胖、糖尿病和抑郁/焦虑等疾病有关的处方。有些情况与生活方式的选择有关。为了减少环境中的药物负荷，可能需要在废水处理厂加强控制和处理。然而，除了水费增加外，这还将导致废水处理、嵌入碳和运行碳的成本大幅增加。这还不包括疾病给社会带来的更广泛成本，因为一个问题的恶化需要付出双倍的代价。因此，目前的情况是不可持续的，需要颠覆性的变革。这个项目的目的是提供数据和证据来帮助促进这种变化。该项目将侧重于利用强大的质谱分析技术开发水指纹分析方法：对选定的药物目标进行三重四极杆分析，对环境和公共卫生决定因素进行非目标/回顾性分析的高分辨率质谱分析。水指纹技术有可能彻底改变保健服务的提供，因为它可以提供实时和具有成本效益的全社区公共卫生诊断，因为城市水可以被视为社区和周围环境健康状况的诊断媒介。该项目将：1；开发以质谱为重点的时空水指纹图谱框架2。2 .对在萨默河谷收集的纵向样本（废水和接收环境）进行分析，以确定环境和公共卫生决定因素（药品、代谢物、内源性形成的标记物）的时空趋势。进行数据三角测量，以核实环境和公共卫生状况以及风险评估，以便制定和应用一种方法，作为所研究区域公共卫生状况的衡量标准和预估干预措施有效性的工具。