Appalachian Tobacco Regulatory Science Team (AppalTRuST)

阿巴拉契亚烟草监管科学团队 (AppalTRuST)

• 批准号: 10665319
• 负责人: SETH S HIMELHOCH
• 金额: $ 392.32万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-30 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10665319
• 关键词: Address; Adult; Affect; Age; Appalachian Region; Area; Behavior; Biometry; Calibration; Cancer Center; Collaborations; Communities; Community Outreach; County; Data; Data Science; Discipline of Nursing; Disparity; Ecological momentary assessment; Education; Ensure; Environment; Epidemiology; Evaluation; Future; Goals; Heterogeneity; Individual; Informatics; Infrastructure; Kentucky; Knowledge; Link; Marketing; Measures; Medicine; Menthol; Mentors; Methodology; Nicotine; Outcome; Participant; Patient Recruitments; Pattern; Pharmaceutical Preparations; Policies; Population; Probability Samples; Public Health; Randomized; Regulation; Research; Research Institute; Research Personnel; Resources; Rural; Rural Community; Sampling; Science; Shapes; Subgroup; Time; Tobacco; Tobacco use; Traumeel S; Universities; Variant; career; cohort; college; community engaged research; cost efficient; data integration; data warehouse; design; experience; health economics; health equity; innovation; low nicotine content cigarette; multidisciplinary; novel; patient engagement; peri-urban; polytobacco use; programs; prospective; public policy on tobacco; recruit; rural area; rurality; synergism; tobacco advertising; tobacco products; tobacco regulation; tobacco regulatory science; tobacco user; young adult

ABSTRACT The overall goal of the Appalachian Tobacco Regulatory Research Team (AppalTRuST) is to investigate the impact of Federal Drug Administration Center for Tobacco Products (FDA CTP) regulatory policies in rural communities, a vulnerable and understudied population, through collaboration, education and pioneering regulatory scientific research. Our multidisciplinary team will investigate this question with two aims. Aim 1. Facilitate and pioneer regulatory science research in rural communities. Our multidisciplinary team of researchers will evaluate current and potential regulatory policies across Projects 1-3 that are methodologically coherent and interrelated with a focus on the regulatory scientific domains of Behavior, Marketing, and Impact Analysis. P1-P3 will leverage the AppalTRuST Cohort to address the critical regulatory question of whether FDA CTP policy actions will be beneficial, shifting individuals to lower harm products or quitting tobacco in rural communities, or not, in a way that assesses the association between outcomes and level of rurality. P1 will measure the factors associated with tobacco use behaviors of conventional and novel products, including initiation, progression, dual/poly tobacco use, product switching, and cessation-related behaviors across levels of rurality over time. P2 will evaluate how FDA regulations may affect patterns of use for conventional and novel products among young adults across levels of rurality. P3 will use a randomized parallel groups trial to assess the impact of three proposed tobacco regulations using an Experimental Tobacco Marketplace to estimate effects of regulatory policies on use behavior across levels of rurality. Aim 2. Support and create new opportunities for innovative tobacco regulatory science and contribute to the national efforts to advance TCORS research through education and collaboration. The following four cores will support the projects to ensure Center coordination, integration, and collaboration: (1) an Administrative Core to provide efficient, collaborative infrastructure to enhance synergies across the three program projects and four cores as well as collaboration with the wider TCORS community; (2) a Community Outreach and Participant Engagement Core to engage rural and peri-urban Appalachian communities to support our AppalTRuST Cohort; (3) a Biostatistics and Informatics Core to build a centralized, integrated data warehouse supported by statistical and informatics expertise to collect, harmonize, and analyze data and provide statistical support for projects and cores; and (4) a Career Enhancement Core to create a transformative environment offering mentored, multidisciplinary and immersive experiences to expand and support TRS scholars, with emphasis on the impact of regulatory policies in rural areas. Impact: AppalTRuST will provide the scientific resources needed to evaluate the effects of the introduction of novel products and potential restrictions on flavored and high-nicotine products in rural communities so that regulatory decisions will be made using a health equity lens and guided by a definition of rurality that is diverse and heterogeneous.

抽象的 阿巴拉契亚烟草监管研究小组 (AppalTRuST) 的总体目标是调查 联邦药物管理局烟草制品中心 (FDA CTP) 监管政策对农村地区的影响 通过合作、教育和开拓，帮助社区、弱势群体和未得到充分研究的群体 监管科学研究。我们的多学科团队将研究这个问题，有两个目标。 目标 1. 促进和开拓农村社区的监管科学研究。我们的多学科 研究人员团队将评估项目 1-3 中当前和潜在的监管政策 方法论上一致且相互关联，重点关注行为的监管科学领域， 营销和影响分析。 P1-P3 将利用 AppalTruST 队列来解决关键的监管问题 FDA CTP 政策行动是否有益、使个人转向危害较低的产品或是否有益的问题 在农村社区是否戒烟，以评估结果与戒烟之间的关系的方式 农村化水平。 P1 将衡量与传统和新型烟草使用行为相关的因素 产品，包括起始、进展、双重/多种烟草使用、产品转换和戒烟相关 随着时间的推移，不同农村层次的行为。 P2 将评估 FDA 法规如何影响使用模式 为各个农村地区的年轻人提供传统和新颖的产品。 P3将使用随机 平行小组试验使用实验评估三项拟议烟草法规的影响 烟草市场评估监管政策对不同农村地区使用行为的影响。 目标 2. 支持创新烟草监管科学并创造新机会并做出贡献 感谢国家通过教育和合作推进 TCORS 研究的努力。下列 四个核心将支持这些项目，以确保中心的协调、整合和协作：(1) 行政核心提供高效、协作的基础设施，以增强三者之间的协同作用 计划项目和四个核心以及与更广泛的 TCORS 社区的合作； (2) 社区 外展和参与者参与核心，让农村和城郊阿巴拉契亚社区参与 支持我们的 AppalTruST 群体； (3) 生物统计和信息学核心，构建集中、集成的数据 由统计和信息学专业知识支持的仓库，用于收集、协调和分析数据 为项目和核心提供统计支持； (4) 职业提升核心，以创建 变革性的环境提供指导、多学科和身临其境的体验，以扩展和 支持TRS学者，重点关注监管政策对农村地区的影响。影响力：AppalTrust 将提供评估新产品引进效果所需的科学资源和 对农村社区的调味和高尼古丁产品的潜在限制，以便监管决策 将使用健康公平的视角并以多样化和异质性的农村定义为指导。