Droplet based microfluidics for probing the metabolom of cells

用于探测细胞代谢的基于液滴的微流体

• 批准号: 2446523
• 金额: --
• 依托单位: University of Glasgow
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2446523
• 关键词: Droplet; based; microfluidics; probing; metabolom

"Droplet microfluidics have shown exceptional promise for cell and tissue engineering, single cell study, cell testing and sorting. This typically involves complex experiments, which require a microfluidic platform to be able to perform multiple functions on each droplet. In this project, we will focus on different cell types and examine their behavior when exposed to different environments in order to understand how cells can be influenced and how to cause desired differentiations. This application if highly relevant for cell engineering, as well as medical exposure studies.The student will exploit state-of-art microfluidic techniques to design and fabricate new prototypes and devices to probe the response of multiple cell types to different environments. This encompasses the use of established methods like soft-lithography and molding but also requires gaining expertise in more advanced techniques combining microfluidics with optical, dielectrophoretic and acoustical setups. Droplet based microfluidics is essential and the key and the student will become an expert in all aspects of this technology.This project will allow us to both probe cell behavior in controlled environments and to look for beneficial cellular responses."

“液滴微流体技术在细胞和组织工程、单细胞研究、细胞测试和分选方面表现出了非凡的前景。这通常涉及复杂的实验，需要微流体平台能够对每个液滴执行多种功能。在这个项目中，我们将专注于不同的细胞类型，并检查它们在暴露于不同环境时的行为，以了解细胞如何受到影响以及如何引起所需的分化。该应用与细胞工程以及医学暴露研究高度相关。学生将利用最先进的微流体技术来设计和制造新的原型和设备，以探测多种细胞类型对不同环境的反应。这包括使用已建立的方法，如软光刻和成型，但也需要获得更先进的技术，结合微流体与光学，介电泳和声学设置的专业知识。基于液滴的微流体技术是必不可少的，也是关键，学生将成为该技术各个方面的专家。该项目将使我们能够在受控环境中探测细胞行为，并寻找有益的细胞反应。"