Regular Exercise Among Women at Risk for Preeclampsia

有先兆子痫风险的女性定期锻炼

基本信息

  • 批准号:
    6885777
  • 负责人:
  • 金额:
    $ 31.92万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2001
  • 资助国家:
    美国
  • 起止时间:
    2001-08-01 至 2008-04-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (Applicant's abstract): Preeclampsia, the sudden onset of high blood pressure along with proteinuria during pregnancy, is a serious complication affecting nearly one in every 20 pregnancies. It is the main cause of maternal death worldwide, and affects women of all races and socioeconomic groups. Unfortunately, no definitive preventive treatment is currently available for this ominous disease. Scientists now believe that preeclampsia is a disease of the endothelium, due in part to oxidative stress. As such, regular exercise has emerged as a potential preventive measure. This contrasts to daily low dose aspirin or calcium supplement which have failed to demonstrate a significant effect and may have adverse effects. The purpose of this study is to determine if moderate intensity exercise during pregnancy will reduce the incidence of preeclampsia and to assess the process (involving oxidative stress and antioxidant process) hypothesized to explain the effect of exercise on preeclampsia. This is a randomized clinical trial with a total of 250 pregnant subjects at risk for preeclampsia. Eligible subjects will enter a run-in period (i.e., qualifying period) at 14 to 18 weeks gestation. Baseline data to be obtained include demographic information, health history, daily physical activities, cardiovascular fitness level, blood pressure, blood sample for serum iron, transferrin, low density lipoprotein, malondialdehyde, superoxide dismutase. At 18 weeks, compliant subjects will be randomly assigned to either the exercise (40 min., 70 percent VO2max, 5x/week) or sham exercise (control group; 10 min. stretch exercise, 5x/week) condition. For both groups, all baseline measurements will be repeated at 28 weeks (Outcome I). Subjects will continue the exercise regimen after 28 weeks up to her term and as long as it is safe and comfortable. A blood sample will be collected again during labor (Outcome II). Subjects who undergo cesarean section for obstetrical reasons will provide a small amount of subcutaneous tissue at the time of incision to measure endothelial superoxide dismutase. Medical records will be reviewed for additional outcome data (pregnancy/birth outcomes and diagnosis of preeclampsia). Chi-square tests of association and logistic regression analysis will be applied to address the effect of exercise, prediction of preeclampsia, and other pregnancy outcomes. Repeated Measures ANOVA will be applied to assess the effect of exercise on various biological markers. ANCOVA will be applied to control confounding factors.
描述(申请人摘要):先兆子痫,高血压的突然发作, 血压沿着蛋白尿,是一种严重的 几乎每20次怀孕中就有一次发生并发症。这是主要原因 全球孕产妇死亡率,并影响到所有种族和社会经济 组不幸的是,目前还没有明确的预防性治疗方法。 可用于这种不祥的疾病。科学家现在认为先兆子痫是 一种内皮疾病,部分原因是氧化应激。因此,常规 锻炼已成为一种潜在的预防措施。这与日常 低剂量阿司匹林或钙补充剂未能证明 有重大影响,并可能产生不良影响。本研究旨在 以确定在怀孕期间进行中等强度的运动是否会减少 先兆子痫的发病率,并评估过程(涉及氧化应激 和抗氧化过程)假设解释运动对 先兆子痫这是一项随机临床试验,共有250名孕妇 有先兆子痫风险的受试者。合格受试者将进入导入期 (i.e.,合格期)妊娠14至18周。基线数据为 获得的信息包括人口统计学信息、健康史、每日体检、 活动,心血管健康水平,血压,血液样本, 血清铁,转铁蛋白,低密度脂蛋白,丙二醛,超氧化物 歧化酶第18周时,依从性受试者将被随机分配至 锻炼(40分钟,70%最大摄氧量,5次/周)或假运动(对照 组; 10分钟拉伸运动,5次/周)条件。对于这两个群体,所有 基线测量将在第28周重复(结果I)。受试者将 28周后继续锻炼,直到她的任期,只要它 既安全又舒适在分娩过程中将再次采集血样 (成果二)。因产科原因接受剖宫产的受试者 将在切开时提供少量皮下组织, 测定内皮超氧化物歧化酶。将审查医疗记录, 其他结局数据(妊娠/分娩结局和 先兆子痫)。关联的卡方检验和Logistic回归分析 将被应用于解决运动的影响,先兆子痫的预测, 以及其他妊娠结局。重复测量ANOVA将用于评估 运动对各种生物标志物的影响。ANCOVA将应用于 控制混杂因素。

项目成果

期刊论文数量(6)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Association between change in maternal physical activity during pregnancy and infant size, in a sample overweight or obese women.
在超重或肥胖女性样本中,怀孕期间母亲体力活动的变化与婴儿尺寸之间的关联。
  • DOI:
    10.1080/03630242.2020.1779904
  • 发表时间:
    2020
  • 期刊:
  • 影响因子:
    1.6
  • 作者:
    McDonald,SamanthaM;Yeo,SeonAe;Liu,Jihong;Wilcox,Sara;Sui,Xuemei;Pate,RussellR
  • 通讯作者:
    Pate,RussellR
Exploratory analysis of exercise adherence patterns with sedentary pregnant women.
  • DOI:
    10.1097/nnr.0b013e3181dbbd61
  • 发表时间:
    2010-07
  • 期刊:
  • 影响因子:
    2.5
  • 作者:
    Yeo S;Cisewski J;Lock EF;Marron JS
  • 通讯作者:
    Marron JS
Physical activity and pregnancy: past and present evidence and future recommendations.
  • DOI:
    10.1080/02701367.2012.10599138
  • 发表时间:
    2012-12
  • 期刊:
  • 影响因子:
    2.2
  • 作者:
    Downs DS;Chasan-Taber L;Evenson KR;Leiferman J;Yeo S
  • 通讯作者:
    Yeo S
Adherence to walking or stretching, and risk of preeclampsia in sedentary pregnant women.
  • DOI:
    10.1002/nur.20328
  • 发表时间:
    2009-08
  • 期刊:
  • 影响因子:
    2
  • 作者:
    Yeo, SeonAe
  • 通讯作者:
    Yeo, SeonAe
Need for population specific validation of a portable metabolic testing system: a case of sedentary pregnant women.
需要对便携式代谢测试系统进行特定人群验证:以久坐孕妇为例。
  • DOI:
    10.1891/jnum.13.3.207
  • 发表时间:
    2005
  • 期刊:
  • 影响因子:
    0.7
  • 作者:
    Yeo,SeonAe;Ronis,DavidL;Antonakos,CathyL;Roberts,Katherine;Hayashi,Robert
  • 通讯作者:
    Hayashi,Robert
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SEONAE YEO其他文献

SEONAE YEO的其他文献

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{{ truncateString('SEONAE YEO', 18)}}的其他基金

Promoting stretching exercise to reduce cardiovascular health risk in late pregnant women with obesity
促进伸展运动可降低妊娠晚期肥胖妇女的心血管健康风险
  • 批准号:
    10404625
  • 财政年份:
    2019
  • 资助金额:
    $ 31.92万
  • 项目类别:
Promoting stretching exercise to reduce cardiovascular health risk in late pregnant women with obesity
促进伸展运动可降低妊娠晚期肥胖妇女的心血管健康风险
  • 批准号:
    10166957
  • 财政年份:
    2019
  • 资助金额:
    $ 31.92万
  • 项目类别:
REGULAR EXERCISE AMONG WOMEN AT RISK FOR PREECLAMPSIA
有先兆子痫风险的女性定期锻炼
  • 批准号:
    7603706
  • 财政年份:
    2007
  • 资助金额:
    $ 31.92万
  • 项目类别:
REGULAR EXERCISE AMONG WOMEN AT RISK FOR PREECLAMPSIA
有先兆子痫风险的女性定期锻炼
  • 批准号:
    7376505
  • 财政年份:
    2006
  • 资助金额:
    $ 31.92万
  • 项目类别:
REGULAR EXERCISE AMONG WOMEN AT RISK FOR PREECLAMPSIA
有先兆子痫风险的女性定期锻炼
  • 批准号:
    7199821
  • 财政年份:
    2005
  • 资助金额:
    $ 31.92万
  • 项目类别:
Regular Exercise Among Women at Risk for Preeclampsia
有先兆子痫风险的女性定期锻炼
  • 批准号:
    7039786
  • 财政年份:
    2004
  • 资助金额:
    $ 31.92万
  • 项目类别:
Regular Exercise Among Women at Risk for Preeclampsia
有先兆子痫风险的女性定期锻炼
  • 批准号:
    6640774
  • 财政年份:
    2001
  • 资助金额:
    $ 31.92万
  • 项目类别:
Regular Exercise Among Women at Risk for Preeclampsia
有先兆子痫风险的女性定期锻炼
  • 批准号:
    6741418
  • 财政年份:
    2001
  • 资助金额:
    $ 31.92万
  • 项目类别:
Regular Exercise Among Women at Risk for Preeclampsia
有先兆子痫风险的女性定期锻炼
  • 批准号:
    6539394
  • 财政年份:
    2001
  • 资助金额:
    $ 31.92万
  • 项目类别:
Regular Exercise Among Women at Risk for Preeclampsia
有先兆子痫风险的女性定期锻炼
  • 批准号:
    6383723
  • 财政年份:
    2001
  • 资助金额:
    $ 31.92万
  • 项目类别:
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