Jellyfish-collagen hydrogels for culture and differentiation of human mesenchymal stem cells and 3D cartilage bioprinting

该项目符合DTP的工业生物技术主题。BBSRC将工业生物技术定义为利用生物资源生产材料、药物前体或生物药物。这些生物资源包括植物、藻类、微生物和海洋生物。在这个案例中，我们将与一家公司合作，从水母中提取胶原蛋白，用作细胞培养研究的支架。我们将研究一种新开发的斑马鱼来源的胶原蛋白水凝胶是否适合直接分化人类间充质干细胞，并随后作为3D生物打印的生物墨水材料。BBSRC强调需要培养干细胞培养和细胞疗法方面的技术人员，以使英国在再生医学领域保持竞争力。该项目还符合BBSRC对多学科的要求，涉及一个拥有生物技术，细胞生物学，材料科学和3D生物打印专业知识的监督团队，而合作伙伴公司Jellagen则带来了工业制造和加工组件。

The project aligns with the DTP theme of Industrial Biotechnology. BBSRC defines industrial biotechnology as the use of biological resources for producing materials, pharmaceutical precursors or biopharmaceuticals. These biological resources include plants, algae, microorganisms and marine life. In this CASE studentship we will be collaborating with a company that extracts collagen from jellyfish for use as a scaffold in cell culture studies. We will investigate the suitability of a newly-developed jellyfish-derived collagen hydrogel to direct differentiation of human mesenchymal stem cells and later as a bioink material for 3D bioprinting. BBSRC has highlighted the need for preparing skilled people in stem cell culture and cellular-based therapies in order for the UK to remain competitive in the area of regenerative medicine. The project also meets the BBSRC requirement for multidisciplinarity, involving a supervisory team with expertise in biotechnology, cell biology, materials science and 3D bioprinting, whereas the partner company, Jellagen, brings the industrial manufacturing and processing component.