Jellyfish-collagen hydrogels for culture and differentiation of human mesenchymal stem cells and 3D cartilage bioprinting

用于人类间充质干细胞培养和分化以及 3D 软骨生物打印的水母胶原水凝胶

• 批准号: 2449275
• 金额: --
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2449275
• 关键词: Jellyfish; collagen; hydrogels; culture; differentiation

The project aligns with the DTP theme of Industrial Biotechnology. BBSRC defines industrial biotechnology as the use of biological resources for producing materials, pharmaceutical precursors or biopharmaceuticals. These biological resources include plants, algae, microorganisms and marine life. In this CASE studentship we will be collaborating with a company that extracts collagen from jellyfish for use as a scaffold in cell culture studies. We will investigate the suitability of a newly-developed jellyfish-derived collagen hydrogel to direct differentiation of human mesenchymal stem cells and later as a bioink material for 3D bioprinting. BBSRC has highlighted the need for preparing skilled people in stem cell culture and cellular-based therapies in order for the UK to remain competitive in the area of regenerative medicine. The project also meets the BBSRC requirement for multidisciplinarity, involving a supervisory team with expertise in biotechnology, cell biology, materials science and 3D bioprinting, whereas the partner company, Jellagen, brings the industrial manufacturing and processing component.

该项目与工业生物技术的DTP主题相一致。BBSRC将工业生物技术定义为利用生物资源生产材料、药物前体或生物制药。这些生物资源包括植物、藻类、微生物和海洋生物。在这种情况下，我们将与一家从水母中提取胶原蛋白的公司合作，作为细胞培养研究的支架。我们将研究一种新开发的水母来源的胶原水凝胶是否适合指导人骨髓间充质干细胞的分化，并随后作为生物墨水材料用于3D生物打印。BBSRC强调了培养干细胞培养和细胞疗法方面的熟练人才的必要性，以使英国在再生医学领域保持竞争力。该项目还符合BBSRC对多学科的要求，包括一个拥有生物技术、细胞生物学、材料科学和3D生物打印专业知识的监督团队，而合作伙伴公司Jellagen带来了工业制造和加工部件。

项目成果

Characterization of the Biophysical Properties and Cell Adhesion Interactions of Marine Invertebrate Collagen from Rhizostoma pulmo.

• DOI: 10.3390/md21020059
• 发表时间: 2023-01-19
• 期刊: Marine drugs
• 影响因子: 5.4