Fluorinated Fragments: Partially Fluorinated Carbocycles and Heterocycles from Upgrading HFO-1234yf

氟化片段：来自升级 HFO-1234yf 的部分氟化碳环和杂环

• 批准号: 2457867
• 金额: --
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2457867
• 关键词: Fluorinated; Fragments; Partially; Carbocycles; Heterocycles

This project will develop new chemical reactions for the recycling of 2,3,3,3-tetrafluoropropene - a modern refrigerant that is being manufactured on scale. The student will use 2,3,3,3-tetrafluoropropene to prepare new classes of partially fluorinated carbocyclic and heterocyclic ring-systems designed as fragments for drug discovery. The student will use flow chemistry to scale the synthetic methods. They will also build quantitative and data-intensive models to understand the conformational preference of these new partially fluorinated ring systems. Training will be provided in aspects of synthesis, catalysis, computational chemistry, flow chemistry and data analysis.

该项目将开发新的化学反应，用于回收2，3，3，3-异丙烯-一种正在大规模生产的现代制冷剂。学生将使用2，3，3，3-二丙烯来制备新型的部分氟化碳环和杂环系统，这些系统被设计为用于药物发现的片段。学生将使用流动化学来衡量合成方法。他们还将建立定量和数据密集型模型，以了解这些新的部分氟化环系统的构象偏好。将提供合成、催化、计算化学、流动化学和数据分析方面的培训。