SARS-CoV-2-induced dead cell fragments drive viral uptake and inflammation

SARS-CoV-2 诱导的死细胞碎片驱动病毒摄取和炎症

• 批准号: DE240101286
• 负责人: Dr Kha Phan
• 金额: --
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2024-02-07
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE240101286
• 关键词: SARS; CoV; induced; dead; cell

This project will apply advanced cell biology and imaging techniques to investigate how macrophages, which lacks a canonical receptor for viral entry, become infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and elicit inflammatory responses. Its insights into a novel pathway of viral entry is expected to advance our understanding of host-pathogen interaction. The project is intended to uncover the role of SARS-CoV-2-induced dead cell fragmentation in promoting viral uptake and inflammation. Its findings should provide significant scientific, health and economic benefits by informing new research directions on infection and innate immunity as well as future therapeutic designs for infection treatment.

该项目将采用晚期细胞生物学和成像技术来研究如何缺乏病毒入口的规范受体的巨噬细胞感染严重的急性呼吸综合征冠状病毒2（SARS-COV-2）并引起炎症反应。它对病毒进入的新途径的见解有望提高我们对宿主 - 病原体相互作用的理解。该项目旨在揭示SARS-COV-2诱导的死细胞破碎化在促进病毒摄取和炎症中的作用。它的发现应通过为感染和先天免疫的新研究指示以及未来的感染治疗治疗设计提供大量科学，健康和经济利益。