Exploring the role of matrix metalloproteinase 12 (MMP12) in macrophages during bacterial infection
Exploring the role of matrix metalloproteinase 12 (MMP12) in macrophages during bacterial infection
批准号:
nhmrc : GNT1126842
负责人:
Dr Nestor Solis
金额:
$38.48万
依托单位国家:
澳大利亚
项目类别:
Early Career Fellowships
财政年份:
2017
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2017-01-01 至 --
中文摘要
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英文摘要
Golden staph infections incur a high morbidity and mortality in Australia costing AUD150M p.a. One of our strongest lines of defense, white blood cells, are known to secrete an extracellular enzyme, matrix metalloproteinase 12 (MMP12). MMP12 digests and modifies functions of other proteins. We will utilize unbiased large-scale “omics” technologies to identify genes responsible for infection dampening due to MMP12 function. This will allow for better informed drug design to treat superbugs.
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依托单位: