Exploring Scanning Ultrasound (SUS), a novel method to treat and prevent neurodegenerative disease

探索扫描超声（SUS），一种治疗和预防神经退行性疾病的新方法

• 批准号: nhmrc : 1145580
• 负责人: Dr Rebecca Nisbet
• 金额: $ 51.77万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/exploring-scanning-ultrasound-neurodegenerative-disease/1320463
• 关键词: Exploring; Scanning; Ultrasound; SUS; novel

We developed a novel scanning ultrasound (SUS) protocol that clears toxic protein aggregates and restores memory function in mouse models of Alzheimer's disease (AD), without the need for therapeutic agents. Here we aim to determine whether SUS has preventative potential, whether there are synergistic effects, and whether a therapeutic antibody combined with SUS leads to an enhanced therapeutic outcome. Together this will guide the development of an ultrasound therapy in AD patients.

我们开发了一种新的扫描超声（SUS）方案，可以清除阿尔茨海默病（AD）小鼠模型中的有毒蛋白质聚集体并恢复记忆功能，而无需治疗药物。在这里，我们的目的是确定SUS是否具有预防潜力，是否存在协同作用，以及治疗性抗体与SUS联合使用是否会提高治疗效果。总之，这将指导阿尔茨海默病患者超声治疗的发展。