Exploring Scanning Ultrasound (SUS), a novel method to treat and prevent neurodegenerative disease

我们开发了一种新的扫描超声(SUS)协议，可以清除有毒蛋白质聚集体并恢复阿尔茨海默病(AD)小鼠模型的记忆功能，而不需要治疗剂。在这里，我们的目标是确定SUS是否具有预防潜力，是否存在协同作用，以及治疗性抗体与SUS联合是否能提高治疗结果。总而言之，这将指导AD患者超声波疗法的发展。

We developed a novel scanning ultrasound (SUS) protocol that clears toxic protein aggregates and restores memory function in mouse models of Alzheimer's disease (AD), without the need for therapeutic agents. Here we aim to determine whether SUS has preventative potential, whether there are synergistic effects, and whether a therapeutic antibody combined with SUS leads to an enhanced therapeutic outcome. Together this will guide the development of an ultrasound therapy in AD patients.