The Impact of Air Pollution on Respiratory Bacteria and Antibiotic Resistance

空气污染，特别是由颗粒物（PM）引起的空气污染，是全球最大的单一健康风险，PM的增加与呼吸系统疾病的增加相匹配，特别是慢性阻塞性肺病（COPD）。COPD是第三大死亡原因，是一种呼吸系统疾病，涉及肺功能的进行性丧失，其特征在于使疾病恶化的周期性加重。PM是加重的原因，并且在我们关于PM对呼吸道病原体的影响的新工作之后，我们提出PM改变呼吸道微生物组，增强呼吸道感染，从而加重COPD。在本项目中，您将确定PM如何影响COPD患者的鼻咽微生物组，以及与COPD加重相关的病原体。您将确定PM对细菌、COPD急性加重和临床结局的影响之间的相关性。该项目涉及患者接触、体内感染模型、尖端分子微生物学和生物信息学的临床研究。

Air pollution particularly that due to particulate matter (PM), is the largest single global health risk, with increasing PM matching rises in respiratory diseases, notably chronic obstructive pulmonary disease (COPD). COPD, the third largest cause of death, is a respiratory disease that involves progressive loss of lung function and is characterised by periodic exacerbations that worsen the disease. PM is a cause of exacerbation and following our novel work on the effect of PM on respiratory pathogens, we propose that PM changes the respiratory microbiome, potentiating respiratory infection that in turn exacerbates COPD. In this project you will determine how PM affects the nasopharyngeal microbiome of COPD patients, and the pathogens associated with COPD exacerbation. You will establish the correlations between the effect of PM on bacteria, COPD exacerbation, and clinical outcome. The project involves clinical research with patient contact, in vivo infection models, cutting edge molecular microbiology and bioinformatics.