cerebellar Afferent Integration Studied In Vitro

小脑传入整合的体外研究

基本信息

  • 批准号:
    6949158
  • 负责人:
  • 金额:
    $ 23.8万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2004
  • 资助国家:
    美国
  • 起止时间:
    2004-09-15 至 2008-06-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): The cerebellar cortex (Cb) is a continuous neural layer of gray matter made up of identical repeating processing modules. Although the circuitry of these modules is similar for all vertebrates, the cortical surface is highly foliated in birds and mammals with complex regional specializations. Therefore, an analysis of Cb topography and its function is difficult because only a small fraction of cortical area is observed on the exposed folial surface. We posit that a radial system of inputs onto Purkinje cells from segregated Cb afferents and ascending granule cell axons is the primary processing unit of the Cb module. This primary system is acted on by a secondary, orthogonal system of parallel fibers and inhibitory interneurons. The proposed study will test this hypothesis with a unique in vitro turtle Cb preparation with the brainstem and sensory nerves attached. The primary advantage of the flat turtle Cb is that it is thin enough to permit optical recordings of the entire Cb surface during trans-illumination. Using voltage-sensitive absorbance dyes, Cb topography can be characterized from large responses to individual sensory stimuli. The small cortical size also permits a topographic anatomical analysis of afferent inputs based on a complete reconstruction of serial sections. Optical recording and pathway tracing experiments will be performed to reveal how sensory afferents map onto the Cb and how these different maps overlap. This project will focus on the effects of visual and vestibular afferents by measuring optical responses in vitro to natural stimulation or electrical microstimulation within the brainstem. Additional experiments will examine the basic cerebellar module: mossy fiber inputs, the radial and orthogonal axonal outputs of the granule cell and the convergence of excitatory and inhibitory inputs onto the Purkinje cell. Finally, climbing fiber inputs to Cb will be measured anatomically and physiologically to understand their role in plasticity and modulation of information flow through the basic cerebellar module. This in vitro preparation will thereby provide a unique model system for the study of learning and adaptation of motor behaviors.
描述(由申请人提供):小脑皮层(Cb)是由相同的重复处理模块组成的连续的灰质神经层。尽管这些模块的回路在所有脊椎动物中都是相似的,但鸟类和哺乳动物的皮质表面是高度叶状的,具有复杂的区域专门化。因此,分析Cb地形及其功能是困难的,因为在暴露的叶面上只观察到一小部分皮质面积。

项目成果

期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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MICHAEL ARIEL其他文献

MICHAEL ARIEL的其他文献

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{{ truncateString('MICHAEL ARIEL', 18)}}的其他基金

cerebellar Afferent Integration Studied In Vitro
小脑传入整合的体外研究
  • 批准号:
    7262539
  • 财政年份:
    2004
  • 资助金额:
    $ 23.8万
  • 项目类别:
cerebellar Afferent Integration Studied In Vitro
小脑传入整合的体外研究
  • 批准号:
    7082822
  • 财政年份:
    2004
  • 资助金额:
    $ 23.8万
  • 项目类别:
Cerebellar Afferent Integration Studied In Vitro
小脑传入整合的体外研究
  • 批准号:
    6868404
  • 财政年份:
    2004
  • 资助金额:
    $ 23.8万
  • 项目类别:
PROCESSING OF BILATERAL INPUTS TO VESTIBULAR NUCLEUS
前庭核双边输入的处理
  • 批准号:
    6516197
  • 财政年份:
    2000
  • 资助金额:
    $ 23.8万
  • 项目类别:
PROCESSING OF BILATERAL INPUTS TO VESTIBULAR NUCLEUS
前庭核双边输入的处理
  • 批准号:
    6342351
  • 财政年份:
    2000
  • 资助金额:
    $ 23.8万
  • 项目类别:
PROCESSING OF BILATERAL INPUTS TO VESTIBULAR NUCLEUS
前庭核双边输入的处理
  • 批准号:
    6051333
  • 财政年份:
    2000
  • 资助金额:
    $ 23.8万
  • 项目类别:
SYNAPTIC INTEGRATION OF SENSORY AFFERENTS IN BRAINSTEM
脑干中感觉传入的突触整合
  • 批准号:
    2460579
  • 财政年份:
    1995
  • 资助金额:
    $ 23.8万
  • 项目类别:
SYNAPTIC INTEGRATION OF SENSORY AFFERENTS IN BRAINSTEM
脑干中感觉传入的突触整合
  • 批准号:
    2271828
  • 财政年份:
    1995
  • 资助金额:
    $ 23.8万
  • 项目类别:
SYNAPTIC INTEGRATION OF SENSORY AFFERENTS IN BRAINSTEM
脑干中感觉传入的突触整合
  • 批准号:
    2271829
  • 财政年份:
    1995
  • 资助金额:
    $ 23.8万
  • 项目类别:
DIRECTIONALLY SENSITIVE INPUT TO OCULOMOTOR PATHWAYS
动眼神经通路的方向敏感输入
  • 批准号:
    3070180
  • 财政年份:
    1989
  • 资助金额:
    $ 23.8万
  • 项目类别:
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