DIRECTIONALLY SENSITIVE INPUT TO OCULOMOTOR PATHWAYS

需要为ADAMHA RSDA II级申请资金，以实现该原则 调查员(私家侦探)调查在方向性上的职能作用 敏感(DS)细胞在视觉诱发行为中发挥作用。私家侦探来了 他四岁了。作为助理教授，跟踪4年。作为博士后 伙计。既然他的实验室已经建立， 学术界减缓了他近期的实验目标以及他的长期目标 职业成长。这项裁决将使私家侦探从其他义务中解脱出来 允许开发独特的神经科学方法来解决 了解信息处理和感觉-运动整合。 私家侦探和行为部的研究目标 神经科学的目标是了解大脑的控制 通过使用当前的神经科学方法对行为进行研究。私家侦探会抽签 基于他所在部门相当多的神经科学专业知识 匹兹堡大学致力于体外培养技术的开发 脑神经生理学，并与他的方法相结合 完整系统的药理学和感受野分析。 DS视网膜神经节细胞是眼睛的输出神经元， 选择性地只向一个方向移动的刺激。他们将会是 被研究为可能输入到稳定的复杂大脑系统 通过控制眼睛的位置在视网膜上显示图像。私家侦探目前 资助进行实验，比较大脑中神经元的反应 麻醉动物至清醒动物的视动性眼震(OKN)。 然而，最近，一种使用海龟的体外制剂正在进行中 为研究动眼神经而开发的。这种制剂具有独特的 优势是整个系统保持完整和可行，因此DS 体外脑中的细胞对投射的视觉刺激做出反应 连在一起的眼睛上。 研究这些反射的体外方法的进展 行为需要新的技能才能让私家侦探完善这些技术 将产生新的工具用于研究大脑的控制 行为过激。这些实验可以涉及到感觉运动。 从感觉特征提取的细胞基础到 感觉通路汇聚到运动输出通路。 OKN对视觉图像的稳定是感官的一个简单模型- 运动行为。对人类来说，一种相关眼球运动功能的紊乱 是精神分裂症的征兆。有关眼球运动控制的知识可能 OKN鉴别视网膜病变的诊断价值 正常和疾病患者眼动行为的中枢控制 各州。

Funds are requested for an ADAMHA RSDA Level II to enable the principle investigator (P.I.) to investigate the functional role that directionally sensitive (DS) cells play in visually evoked behaviors. The P.I. is in his 4th yr. as an Asst. Professor following 4 yrs. as a Postdoctoral Fellow. Now that his laboratory is established, the constraints of academia slow his immediate experimental goals as well as his long-term professional growth. This award will free the P.I. from other commitments to allow for the development of unique neuroscience approaches to the understanding of information processing and sensory-motor integration. The research goals of the P.I. and the Department of Behavior Neuroscience are directed towards an understanding of the brain's control of behavior by using current neuroscience approaches. The P.I. will draw upon the considerable neuroscience expertise of his department and the University of Pittsburgh at large to development techniques of in vitro brain neurophysiology and combine them with his approaches of pharmacology and receptive field analysis of an intact system. DS retinal ganglion cells are output neurons of the eye that respond selectively to stimuli moving only in one direction. They will be studied as a possible input to a complex brain system which stabilizes images on the retina by controlling eye position. The P.I. is currently funded to perform experiments which compare neuronal responses in the anaesthetized animal to optokinetic nystagmus (OKN) in the awake animal. Recently though, an in vitro preparation using the turtle is being developed for oculomotor research. This preparation has the unique advantage that the entire system remains intact and viable, so that DS cells in the extracorporeal brain respond to visual stimuli projected onto the attached eyes. The development of in vitro approaches to the study of these reflex behaviors require new skills for the P.I. Perfecting these techniques will produce new tools to use in investigations of the brain's control over behavior. These experiments can then involve sensory-motor integration from the cellular basis of sensory feature extraction to the convergence of sensory pathways onto motor output pathways. Stabilization of the visual image by OKN is a simple model of a sensory- motor behavior. In humans, a disorder of a related eye movement function is an indication of schizophrenia. Knowledge of oculomotor control may further OKN's diagnostic usefulness by differentiating between retinal and central control of eye movement behaviors in normal and disease states.