Amplified Self-Immolative Elimination of AMP-Drug Conjugates

AMP-药物缀合物的放大自毁消除

• 批准号: 2468554
• 金额: --
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2468554
• 关键词: Amplified; Self; Immolative; Elimination; AMP

Year 1: Generic training activities for all first-year student members of the CDT.Year 2-4: There is growing need for effective antimicrobial agents to fight against the antimicrobial resistance crisis. Many known antibiotics fail to be effective against Gram-negative bacteria due to poor membrane permeability, inducing the need for large doses that lead to toxicity and so fail as therapeutics. Antimicrobial peptides (AMPs) are a naturally-occurring class of antibiotics. They are found in all forms of life and are adept at membrane penetration. Conjugation of AMPs with antibiotics allow for an effective therapy while decreasing the chance of resistance forming. Conjugates with self-immolative linkers enable the release of the constituent therapeutics in the presence of a specific chemical trigger, thus increasing the selectivity for the target. Additionally, an amplified self-disassembling system can be used for multiple drug molecule release, increasing the potency of the conjugate.

第一年：为CDT所有一年级学生成员提供一般培训活动。第2-4年：越来越需要有效的抗微生物药物来对抗抗微生物药物耐药性危机。由于膜渗透性差，许多已知的抗生素对革兰氏阴性菌无效，导致需要大剂量导致毒性，因此不能作为治疗药物。抗菌肽（AMPs）是一类天然存在的抗生素。它们存在于所有形式的生命中，擅长穿透膜。amp与抗生素的结合允许有效的治疗，同时减少耐药性形成的机会。与自焚连接物的偶联物能够在特定化学触发物存在的情况下释放成分疗法，从而增加对靶标的选择性。此外，放大的自拆卸系统可用于多种药物分子释放，增加了缀合物的效力。