Combining cutting edge molecular microbiology and super-resolution microscopy to reveal how bacteria divide, and how to stop them

结合尖端分子微生物学和超分辨率显微镜，揭示细菌如何分裂以及如何阻止它们

• 批准号: 2469621
• 金额: --
• 依托单位: Newcastle University
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2469621
• 关键词: Combining; cutting; edge; molecular; microbiology

During this PhD we will use super-resolution microscopy to reveal how the septum is built, and how antimicrobials physically compromise septum integrity. This strongly AMR-relevant discovery science project aims to reveal critical, potentially druggable, weak links in bacterial division. This work will be performed in the primary Gram-positive model organism Bacillus subtilis. Due to the highly conserved nature of cell division proteins, insight gained here is directly relevant to pathogens such as MRSA and Streptococcus pneumoniae.

在这个博士学位期间，我们将使用超分辨率显微镜来揭示隔膜是如何构建的，以及抗菌剂如何在物理上损害隔膜的完整性。这个与AMR密切相关的发现科学项目旨在揭示细菌分裂中关键的、潜在的可药物化的薄弱环节。这项工作将在主要革兰氏阳性模式生物枯草芽孢杆菌中进行。由于细胞分裂蛋白的高度保守性，在这里获得的见解与MRSA和肺炎链球菌等病原体直接相关。