Non canonical cytokine signalling of haematopoietic growth factors in nociceptor

伤害感受器中造血生长因子的非典型细胞因子信号传导

• 批准号: 2471661
• 金额: --
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2471661
• 关键词: Non; canonical; cytokine; signalling; haematopoietic

The ability to detect, respond to and effectively repair tissue damage following injury or infection is critical to an organism's long-term survival. Integral to this is the interaction between inflammation and pain, through the sensitisation of nociceptive pathways in the injured or infected tissue. Behaviourally, this protective response manifests as hyperalgesia and allodynia through the activation and sensitisation of pain-sensing neurones to thermal, chemical and mechanical stimuli. Multiple mediators are released by resident or recruited blood-derived immune cells that are capable of sensitising pain pathways, and of these, cytokines play a critical role. However, in many cases, the mechanisms by which cytokines induce pain and sensitise nociceptors are poorly understood.

在损伤或感染后检测、响应和有效修复组织损伤的能力对生物体的长期存活至关重要。与此不可分割的是炎症和疼痛之间的相互作用，通过在受伤或感染的组织中的伤害性通路的敏感化。在行为上，这种保护性反应表现为痛觉过敏和异常性疼痛，通过激活和敏化疼痛感测神经元的热，化学和机械刺激。多种介质由能够使疼痛通路敏感的常驻或募集的血液来源的免疫细胞释放，并且其中，细胞因子起关键作用。然而，在许多情况下，细胞因子诱导疼痛和致敏伤害感受器的机制知之甚少。