A randomised trial of surgery versus surgery plus radiotherapy for regional control in patients with stage 3 melanoma

一项针对 3 期黑色素瘤患者进行区域控制的手术与手术加放疗的随机试验

• 批准号: nhmrc : 454745
• 负责人: A/Pr Angela Hong
• 金额: $ 20.35万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/randomised-trial-surgery-3-melanoma/81714
• 关键词: randomised; trial; surgery; versus; plus

Melanoma is a common disease in Australia. When it has spread to lymph glands it has a poor prognosis. If not controlled it can lead to severe local symptoms including pain, bleeding and disabilty. This is a world first clinical trial involving radiotherapy given after surgery for melanoma involving regional lymph glands. It involves a head to head comparison of surgery alone versus surgery followed by radiotherapy. The target is 230 patients, more than 160 being so far recruited. The main outcome of the study is control of melanoma in the lymph gland basin. Other outcomes are survival, time to recurrence, side-effects (such as lymphoedema) and quality of life. The trial currently involves 13 centres in Australia, New Zealand and the Netherlands. It is expects to be completed in 2007.

黑色素瘤是澳大利亚的常见病。当它扩散到淋巴腺时，它的预后很差。如果不加以控制，它可能会导致严重的局部症状，包括疼痛、出血和残疾。这是世界上第一个涉及区域淋巴腺的黑色素瘤手术后进行放射治疗的临床试验。它涉及单独手术和手术后放射治疗的面对面比较。目标是230名患者，到目前为止已经招募了160多名患者。这项研究的主要结果是控制了淋巴腺盆地中的黑色素瘤。其他结果包括存活率、复发时间、副作用(如淋巴水肿)和生活质量。该试验目前涉及澳大利亚、新西兰和荷兰的13个中心。预计将于2007年完工。